TABLE 1.
In vitro susceptibility of urinary Candida isolates to fluconazole, voriconazole, and amphotericin B in 1994 and 1998
| Antifungal agent | Determination |
C. albicans
|
C. tropicalis
|
C. glabrata
|
|||
|---|---|---|---|---|---|---|---|
| 1994 (n = 21) | 1998 (n = 30) | 1994 (n = 7) | 1998 (n = 4) | 1994 (n = 12) | 1998 (n = 6) | ||
| Fluconazole | MIC50 (range)a | 0.25 (0.125–>64) | 0.50 (0.25–>64) | 1 (0.5–4) | 2 (1–>64) | 16 (4–>64) | 16 (4–32) |
| Geometric meanb | 0.36 | 0.65 | 1.35 | 4.00 | 16.95 | 16.00 | |
| % resistantc | 4 | 6.7 | 0 | 25 | 66.7 | 66.7 | |
| Voriconazole | MIC50 (range) | 0.03 (0.03–1) | 0.03 (0.03–0.25) | 0.06 (0.03–2) | 0.06 (0.06–1) | 0.5 (0.25–4) | 0.5 (0.25–1) |
| Geometric mean | 0.05 | 0.04 | 0.13 | 0.15 | 0.6 | 0.56 | |
| Amphotericin B | MIC50 (range) | 0.5 (0.5–1) | 1 (0.5–1) | 1 (1) | 1 (1–2) | 1 (1) | 1 (1) |
| Geometric mean | 0.65 | 0.85 | 1.00 | 1.19 | 1.00 | 1.00 | |
a
MIC50, range, and means are expressed in micrograms per milliliter.
b
For calculation of the geometric mean, a MIC of >64 μg/ml was assumed to be 64 μg/ml.
c
Percent resistant was defined as dose-dependent susceptibility (MIC of 16–32 μg/ml) or total resistance (MIC of ≥64 μg/ml).