Figure 5.

Assessment of transcriptional and protein levels of key epigenetic-related genes. (a,d) Dnmt1, Dnmt3b, Tet1, Tet2, Tet3, Hdac2, Hdac3 and Hdac8 gene transcriptional levels by real-time RT-PCR in TNBC PDX tumors in control and GE treatment groups, (b,e) Protein levels of these key epigenetic-related genes by Western blot, (c,f) Histograms showed quantification of protein levels. Gapdh or β-Actin was used as internal control. Data shown are representative of three independent experiments (n = 3/patient/group). Columns, mean; Bars, SD; * p < 0.05, ** p < 0.01, significantly different from control group.