Table 1.
Representative causative genes of dilated cardiomyopathy.
| Functional Group | Gene | Protein |
|---|---|---|
| Sarcomere | TTN | Titin |
| ACTC1 | α-Cardiac actin | |
| MYH7 | β-Myosin heavy chain | |
| TNNC1 | Cardiac troponin C | |
| TNNT2 | Cardiac troponin T | |
| TNNI3 | Cardiac troponin I | |
| Nuclear Envelope | LMNA | Lamin A/C |
| EMD | Emerin | |
| Desmosomes | DSP | Desmoplakin |
| DSG2 | Desmoglein 2 | |
| DSC2 | Desmocollin 2 | |
| Cytoskeleton | DES | Desmin |
| VCL | Vinculin | |
| FLNC | Filamin C | |
| Z-disk | BAG3 | BCL2-associated athanogene 3 |
| CSRP3 | Muscle LIM protein | |
| MYPN | Myopalladin | |
| Ion channels | SCN5A | Sodium channel protein type 5 |
| Sarcoplasmic reticulum | PLN | Phospholamban |
| RYR2 | Ryanodine receptor 2 | |
| Others | RBM20 | RNA-binding protein 20 |