Table 2.
Representative causative genes of hypertrophic cardiomyopathy.
| Functional Group | Gene | Protein |
|---|---|---|
| Sarcomere (Thick Filament) | MYBPC3 | Myosin-binding protein C |
| MYH7 | β-Myosin heavy chain | |
| MYL2 | Myosin light chain 2 | |
| MYL3 | Myosin light chain 3 | |
| TTN | Titin | |
| Sarcomere (Thin Filament) | TNNC1 | Cardiac troponin C |
| TNNT2 | Cardiac troponin T | |
| TNNI3 | Cardiac troponin I | |
| TPM1 | Tropomyosin α-1 | |
| ACTC1 | α-Cardiac actin | |
| Others | ACTN2 | α-Actinin 2 |
| CSRP3 | Muscle LIM protein | |
| FLNC | Filamin C | |
| PLN | Phospholamban | |
| ALPK3 | α-Protein kinase 3 |