Table 2.
Hardy–Weinberg’s law for patients with polysubstance use disorder comorbid with a depressive episode (PUD MDD), for patients diagnosed with polysubstance use disorder (PUD) and control subjects.
| Hardy–Weinberg Equilibrium Calculator Including Analysis for Ascertainment Bias | Observed (Expected) | Test χ2 | |||
|---|---|---|---|---|---|
| χ2 | p | ||||
| DRD4 Ex3 PUD MDD | s/s | 63 (64) | l allele freq = 0.18 s allele freq = 0.82 |
0.529 | >0.05 |
| s/l | 30 (27.9) | ||||
| l/l | 2 (3) | ||||
| DRD4 Ex3 PUD | s/s | 127 (128.2) | l allele freq = 0.21 s allele freq = 0.79 |
0.245 | >0.05 |
| s/l | 71 (68.6) | ||||
| l/l | 8 (9.2) | ||||
| DRD4 Ex3 control subjects | s/s | 177 (169.7) | l allele freq = 0.25 s allele freq = 0.75 |
5.075 | <0.05 |
| s/l | 98 (112.6) | ||||
| l/l | 26 (18.7) | ||||
p, statistical significance χ2 test; s, short; l, long.