Table 5.
Differences in DRD4 exon 3 (DRD4 Ex3), the NEO Five Factor Inventory, and the STAI scale between healthy controls and PUD MDD subjects.
| STAI/NEO Five Factor Inventory | DRD4 Ex3 | ANOVA | |||||||
|---|---|---|---|---|---|---|---|---|---|
| PUD MDD (n = 95) | Control (n = 301) |
s/s (n = 240) |
s/l (n = 127) |
l/l (n = 28) |
Factor | F (p-Value) | ɳ2 | Power (Alfa = 0.05) | |
| STAI trait/scale | 7.62 ± 2.25 | 5.16 ± 2.17 | 5.72 ± 2.54 | 5.87 ± 2.21 | 5.32 ± 2.34 | intercept | F1,389 = 499.54 (p < 0.0001) * | 0.563 | 1.000 |
| PUD MDD/control | F1,389 = 17.06 (p < 0.000) * | 0.042 | 0.985 | ||||||
| DRD4 Ex3 | F2,389 = 0.02 (p = 0.976) | 0.0001 | 0.054 | ||||||
| PUD MDD/control × DRD4 Ex3 | F2,389 = 0.64 (p = 0.527) | 0.003 | 0.157 | ||||||
| STAI state/scale | 6.65 ± 2.21 | 4.68 ± 2.14 | 5.10 ± 2,33 | 5.39 ± 2.24 | 4.61 ± 2.39 | intercept | F1,389 = 386.18 (p < 0.0001) * | 0.498 | 1.000 |
| PUD MDD/control | F1,389 = 8.40 (p = 0.004) * | 0.021 | 0.824 | ||||||
| DRD4 Ex3 | F2,389 = 0.88 (p = 0.415) | 0.004 | 0.201 | ||||||
| PUD MDD/control × DRD4 Ex3 | F2,389 = 0.32 (p = 0.729) | 0.002 | 0.100 | ||||||
| Neuroticism/scale | 7.34 ± 2.00 | 4.67 ± 2.01 | 5.31 ± 2.27 | 5.45 ± 2.32 | 4.50 ± 2.51 | intercept | F1,389 = 515.96 (p < 0.0001) * | 0.571 | 1.000 |
| PUD MDD/control | F1,389 = 26.51 (p < 0.0001) * | 0.064 | 0.999 | ||||||
| DRD4 Ex3 | F2,389 = 0.73 (p = 0.480) | 0.004 | 0.174 | ||||||
| PUD MDD/control × DRD4 Ex3 | F2,389 = 0.04 (p = 0.954) | 0.0002 | 0.057 | ||||||
| Extraversion/scale | 5.44 ± 2.36 | 6.37 ± 1.97 | 6.20 ± 2.04 | 5.90 ± 2.19 | 6.89 ± 2.11 | intercept | F1,389 = 588.12 (p < 0.0001) * | 0.602 | 1.000 |
| PUD MDD/control | F1,389 = 0.003 (p = 0.953) | 0.00001 | 0.050 | ||||||
| DRD4 Ex3 | F2,389 = 6.23 (p = 0.002) * | 0.031 | 0.893 | ||||||
| PUD MDD/control × DRD4 Ex3 | F2,389 = 4.22 (p = 0.015) * | 0.021 | 0.738 | ||||||
| Openness/scale | 5.46 ± 2.01 | 4.53 ± 1.61 | 4.64 ± 1.77 | 4.96 ± 1.74 | 4.75 ± 1.67 | intercept | F1,389 = 568.45 (p < 0.0001) * | 0.594 | 1.000 |
| PUD MDD/control | F1,389 = 9.83 (p = 0.002) * | 0.024 | 0.879 | ||||||
| DRD4 Ex3 | F2,389 = 1.66 (p = 0.190) | 0.008 | 0.350 | ||||||
| PUD MDD/control × DRD4 Ex3 | F2,389 = 0.88 (p = 0.416) | 0.004 | 0.201 | ||||||
| Agreeability/scale | 4.05 ± 1.99 | 5.60 ± 2.09 | 5.12 ± 2.21 | 5.41 ± 2.12 | 5.36 ± 1.97 | intercept | F1,389 = 313.18 (p < 0.0001) * | 0.447 | 1.000 |
| PUD MDD/control | F1,389 = 9.69 (p = 0.002) | 0.024 | 0.874 | ||||||
| DRD4 Ex3 | F2,389 = 2.37 (p = 0.554) | 0.003 | 0.142 | ||||||
| PUD MDD/control × DRD4 Ex3 | F2,389 = 0.30 (p = 0.071) | 0.0004 | 0.061 | ||||||
| Conscientiousness/scale | 5.01 ± 2.14 | 6.07 ± 2.15 | 5.80 ± 2.21 | 5.75 ± 2.18 | 6.39 ± 2.10 | intercept | F1,389 = 510.13 (p < 0.0001) * | 0.568 | 1.000 |
| PUD MDD/control | F1,389 = 0.18 (p = 0.668) | 0.0005 | 0.071 | ||||||
| DRD4 Ex3 | F2,389 = 5.09 (p = 0.007) * | 0.026 | 0.820 | ||||||
| PUD MDD/control × DRD4 Ex3 | F2,389 = 5.24 (p = 0.006) * | 0.026 | 0.831 | ||||||
* Significant result.