Table 1.
Final fluke infection parameters for the control and vaccination groups. Recovered fluke burdens, fluke wet weights, fecal egg counts, and host liver pathology values for animals within Group 1 (subcutaneous PBS vaccination), Group 2 (intranasal rLTB-FhTSP2 vaccination), and Group 3 (subcutaneous rFhTSP2 vaccination).
| Group | Treatment (Delivery) | Fluke Burdens (mean ± SD) | Efficacay (% Protection) | Fluke Wet Weight (mean ± SD) | Fecal Egg Count (mean ± SD) | Egg Count Reduction | Liver Pathology Score (mean ± SD) |
|---|---|---|---|---|---|---|---|
| 1 | Control PBS (sc) |
48, 63, 66, 68, 77, 111 (72.2 ± 21.2) |
- | 1.2, 1.8, 2, 2, 3.9, 4.4 (2.6 ± 1.3) |
1, 3, 3, 3, 4, 23 (6.2 ± 8.3) |
- | 1, 2, 2, 2, 2, 3 (2 ± 0.6) |
| 2 | rLTB-FhTSP2 (in) |
23, 43, 46, 62, 91, 94 (59.8 ± 28.2) |
17% | 0.6, 1, 1.5, 2, 2, 2.1 (1.7 ± 0.4) |
1, 1, 1, 1, 2, 4 (1.7 ± 1.2) |
73% | 1, 2, 2, 2, 2, 2 (1.8 ± 0.4) |
| 3 | rFhTSP2 (sc) |
25, 66, 72, 88, 92, 97 (73.3 ± 26.5) |
−1.6% | 0.6, 1.7, 2.4, 2.5, 3.1, 3.7 (2.3 ± 1.1) |
0, 1, 2, 6, 10, 16 (5.8 ± 6.2) |
5% | 1, 2, 2, 2, 2, 2 (1.8 ± 0.4) |