Comparison 1. Multi‐component delirium prevention intervention (MCI) versus usual care.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1.1 Incident Delirium	14	3693	Risk Ratio (M‐H, Random, 95% CI)	0.57 [0.46, 0.71]
1.1.1 Medical patients	6	1460	Risk Ratio (M‐H, Random, 95% CI)	0.61 [0.45, 0.83]
1.1.2 Surgical patients	7	1520	Risk Ratio (M‐H, Random, 95% CI)	0.49 [0.34, 0.72]
1.1.3 Mixed medical and surgical	1	713	Risk Ratio (M‐H, Random, 95% CI)	0.78 [0.47, 1.30]
1.2 Inpatient mortality	10	2640	Risk Ratio (M‐H, Random, 95% CI)	1.17 [0.79, 1.74]
1.3 Mortality at 1 to 3 months	3	1200	Risk Ratio (M‐H, Random, 95% CI)	1.26 [0.92, 1.75]
1.4 Mortality at 12 months	1	199	Risk Ratio (M‐H, Random, 95% CI)	0.85 [0.46, 1.56]
1.5 Duration of delirium episode	6	351	Mean Difference (IV, Random, 95% CI)	‐0.93 [‐2.01, 0.14]
1.6 Peak severity of delirium	5	147	Std. Mean Difference (IV, Random, 95% CI)	‐0.49 [‐1.13, 0.14]
1.7 Length of hospital stay	10	3351	Mean Difference (IV, Random, 95% CI)	‐1.30 [‐2.56, ‐0.04]
1.8 Withdrawal from protocol	6	1751	Risk Ratio (M‐H, Random, 95% CI)	1.03 [0.60, 1.75]
1.9 Readmission to hospital	2	401	Risk Ratio (M‐H, Random, 95% CI)	1.35 [0.89, 2.07]
1.10 New care home admission on discharge	1	536	Risk Ratio (M‐H, Random, 95% CI)	0.77 [0.55, 1.07]
1.11 Falls	6	1680	Risk Ratio (M‐H, Random, 95% CI)	0.56 [0.35, 0.90]
1.12 Pressure ulcers	2	457	Risk Ratio (M‐H, Random, 95% CI)	0.48 [0.26, 0.89]
1.13 Incidence of delirium in patients with dementia	1	126	Risk Ratio (M‐H, Random, 95% CI)	0.73 [0.41, 1.32]
1.13.1 Individuals with dementia	1	50	Risk Ratio (M‐H, Random, 95% CI)	0.90 [0.59, 1.36]
1.13.2 Individuals without dementia	1	76	Risk Ratio (M‐H, Random, 95% CI)	0.50 [0.22, 1.13]