Table 1.
Resistance to 10 antibiotic categories and ESBL production of 126 UPEC O25b clinical strains.
| Antibiotic (µg) |
Phylogenetic Group n (%) | TR (n = 126) |
||||
|---|---|---|---|---|---|---|
| A1 (n = 6) |
B21 (n = 12) |
B22 (n = 76) |
D1 (n = 18) |
D2 (n = 14) |
||
| Penicillins | ||||||
| AM-10 | 6 (100) | 12 (100) | 76 (100) | 18 (100) | 13 (92.86) | 125 (99.20) |
| β-Lactam/combination agents | ||||||
| AMC-20/10 | 6 (100) | 11 (91.7) | 52 (68.42) | 15 (83.33) | 14 (100) | 98 (77.77) |
| TZP-100/10 | 6 (100) | 12 (100) | 70 (92.11) | 15 (83.33) | 14 (100) | 117 (92.85) |
| Cephems 1st and 2rd | ||||||
| CF-30 | 6 (100) | 12 (100) | 71 (93.42) | 8 (44.44) | 11 (78.57) | 108 (85.71) |
| CEC-30 | 6 (100) | 9 (75) | 73 (96.05) | 8 (44.44) | 9 (64.29) | 105 (83.33) |
| Cephems 3nd | ||||||
| CTX-30 | 6 (100) | 8 (66.7) | 72 (94.74) | 4 (22.22) | 8 (57.14) | 98 (77.77) |
| CAZ-30 | 6 (100) | 8 (66.7) | 72 (94.74) | 4 (22.22) | 8 (57.14) | 98 (77.77) |
| Monobactams | ||||||
| ATM-30 | 6 (100) | 7 (58.33) | 68 (89.47) | 5 (27.78) | 6 (42.86) | 92 (73.01) |
| Carbapenems | ||||||
| MEM-10 | 0 (0) | 2 (16.7) | 1 (1.31) | 2(11.11) | 5 (35.71) | 10 (7.94) |
| IPM-10 | 0 (0) | 2 (16.7) | 1 (1.31) | 2 (11.11) | 5 (35.71) | 10 (7.94) |
| Aminoglycosides | ||||||
| GM-10 | 4 (66.7) | 5 (41.7) | 42 (55.26) | 11 (61.11) | 7 (50) | 69 (54.76) |
| Tetracyclines | ||||||
| TE-30 | 6 (100) | 10 (83.33) | 65 (85.52) | 15 (83.33) | 11 (78.57) | 107 (84.92) |
| Fluoroquinolones | ||||||
| LVX-5 | 6 (100) | 6 (50) | 73 (96.05) | 6 (33.33) | 7 (50) | 98 (77.77) |
| NOR-10 | 6 (100) | 6 (50) | 73 (96.05) | 6 (33.33) | 7 (50) | 98 (77.77) |
| OFX-5 | 6 (100) | 6 (50) | 73 (96.05) | 6 (33.33) | 7 (50) | 98 (77.77) |
| Folate pathway antagonists | ||||||
| SXT-1.25/23.75 | 3 (50) | 3 (25) | 44 (57.87) | 13 (72.22) | 7 (50) | 70 (55.55) |
| Nitrofurans | ||||||
| F/M-300 | 2 (33.3) | 1 (8.33) | 4 (5.26) | 1 (5.56) | 2 (14.29) | 10 (7.94) |
| ESBLs | ||||||
| 5 (83.33) | 8 (66.66) * | 59 (77.63) ^ + | 3 (16.66) *^ | 6 (42.85) + | 81 (64.28) | |
| Integrons | ||||||
| Int-1 (intl1) | 4 (66.66) | 2 (16.66) °ꝏ | 37 (48.68) ° | 10 (55.55) ꝏ | 7 (50.00) | 60 (47.61) |
| Int-2 (intl2) | 1 (16.66) | 1 (8.33) | 2 (2.63) | 0 (0.00) | 0 (0.00) | 4 (3.17) |
AM-10 (ampicillin), AMC-20/10 (amoxicillin–clavulanate), TZP-100/10 (piperacillin–tazobactam), CF-30 (cefalotin), CEC-30 (cefaclor), CTX-30 (cefotaxime), CAZ-30 (ceftazidime), ATM-30 (aztreonam), MEM-10 (meropenem), IPM-10 (imipenem), GM-10 (gentamicin), TE-30 (tetracycline). LVX-5 (levofloxacin), NOR-10 (norfloxacin), OFX-5 (ofloxacin), SXT-1.25/23.75 (trimethoprim–sulfamethoxazole), F/M-300 (nitrofurantoin), TR (total resistance), Int-1 (integrase class 1), Int-2 (integrase class 2), and 1st, 2nd and 3rd (generation of cephems). Statistically significant: * p = 0.0024; ^ p < 0.0001; + p = 0.0066; ° p = 0.0404, and ꝏ p = 0.0380.