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Effect of hydroxamic acids with a natural origin CAP group on β-amyloid 1–40 (A–D) and 1–42 (E–H) aggregation. A, E—the concentration of the test compounds is 100 μM. Concentration dependences of inhibition of Aβ1–40 and Aβ1–42 aggregation by hydroxamic acids 15—B and F, 24—C and G, 25—D and H. The data are presented as % β-amyloid aggregation relative to the maximum fluorescence value of Thioflavin T.
