Figure 7.

Effect of hydroxamic acids 15 and 25 on the overall behavior of 5xFAD transgenic animals in the open field test. (A)—experimental design of the open field test; (B)—number of standing events as the indicator of explorative behavior; (C,D)—distance of movement and mean movement rate as parameters of locomotor activity; (E,F)—time spent in central and peripheral areas as indicators of the anxiety level in mice. Data are shown as mean ± SEM (number of animals in each group, n = 8). The statistical analysis was performed using one-way ANOVA and the Bonferroni test. The circles in Figures B–F indicate the individual result of each animal in the experimental groups.