Figure 8.

Effect of hydroxamic acids 15 and 25 on episodic memory of 5xFAD transgenic animals in the Novel Object Recognition Test. (A)—experimental design of the Novel Object Recognition Test; (B)—the percentage of the object exploration during the 10 min test phase of the object recognition task. The times spent exploring each object are shown as a ratio of the total time spent exploring both objects. Data are shown as mean ± SEM (number of animals in each group, n = 8). * and **, p < 0.05 and p < 0.01, respectively, versus 5xFAD mice. The circles in Fugure B indicate the individual result of each animal in the experimental groups. The statistical analysis was performed using two-way ANOVA and the Bonferroni test.