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. 2021 Nov 8;13(11):1893. doi: 10.3390/pharmaceutics13111893

Figure 12.

Figure 12

Ex vivo analysis of the activity of the electron transport chain complexes in the mice’s brain mitochondria post-mortem pretreated with hydroxamic acids 15 (A) and 25 (B) after in vivo experiments. The concentration of rotenone is 2 μM, potassium succinate—2 μM, antimycin—4 μM, ascorbate/TMPD—0.5 μM. Data are shown as mean ± SEM. **, ***, ****, p <0.01, p <0.001 and p < 0.0001, respectively, versus 5xFAD mice.