Table 2.
Antioxidant status and HDAC6-inhibiting ability of hydroxamic acids with a natural origin CAP group.
| % of Activity * | IC50 HDAC6 Inhibitory Activity, µM | |||
|---|---|---|---|---|
| Inhibition of LPO | Antiradical Activity | |||
| t-BHP | Fe (II) | |||
| Trolox | 99.11 ± 3.72 | 97.21 ± 4.09 | - | - |
| Trich. A | - | - | - | 0.03 ± 0.01 |
| 1 | - | - | - | - |
| 2 | - | - | 32.02 ± 3.33 | - |
| 11 | 35.96 ± 1.99 | 28.39 ±7.41 | 22.22 ± 1.40 | 0.69 ± 0.02 |
| 12 | 30.36 ± 1.98 | 44.02 ± 1.57 | - | 4.06 ± 0.48 |
| 13 | 24.02 ± 3.44 | 28.90 ± 3.38 | - | 9.44 ± 0.74 |
| 14 | 22.62 ± 4.31 | 37.91 ± 1.08 | - | 4.48 ± 0.13 |
| 15 | 43.24 ± 1.28 | 21.52 ± 2.15 | 19.70 ± 1.34 | 0.96 ± 0.01 |
| 16 | 16.27 ± 0.42 | 26.41 ± 2.58 | - | 0.74 ± 0.01 |
| 23 | 18.26 ± 4.90 | 32.91 ± 1.12 | 20.14 ± 1.28 | 18.03 ± 1.02 |
| 24 | 20.63 ± 3.92 | 34.16 ± 1.37 | 20.32 ± 0.41 | 4.06 ± 0.39 |
| 25 | 44.59 ± 1.73 | 19.81 ± 4.83 | 43.34 ± 1.42 | 6.52 ± 0.40 |
The data in the table are presented as mean ± SEM. The ‘-’ mark indicates the lack of activity of the test substances (≤10%) in a particular test. *—under the action of substances at a 100 μM concentration.