Table 1.
Ex vivo measurement of EDL muscle force and fatigue. Fatigue was followed during 150 consecutive tetanus.
| TWITCH | TETANUS | |||
|---|---|---|---|---|
| TG2+/+ | TG2−/− | TG2+/+ | TG2−/− | |
| Number of animals | 8 | 7 | 8 | 7 |
| Number of muscles | 14 | 11 | 14 | 11 |
| Muscle weight (mg) | 17.41 ± 0.91 | 16.61 ± 0.55 | - | - |
| Force (mN/mm2) | 1.75 ± 0.24 | 1.47 ± 0.12 | 8.37 ± 1.31 | 7.61 ± 0.63 |
| TTP (ms) | 32.7 ± 1.0 | 31.0 ± 0.6 | 186.9 ± 7.4 | 186.7 ± 5.0 |
| HRT (ms) | 26.5 ± 1.4 | 24.5 ± 1.4 | 74.4 ± 8.2 | 75.7 ± 5.1 |
| Duration (ms) | 205.6 ± 33.3 | 181.2 ± 25.8 | 344.6 ± 8.8 | 343.0 ± 5.2 |
| Muscle venter area (mm2) | 1.36 ± 0.08 | 1.37 ± 0.06 | - | - |
| Fatigue at 50 (%) | - | - | 33.8 ± 1.8 | 37.2 ± 2.3 |
| Fatigue at 100 (%) | - | - | 63.7 ± 1.8 | 63.6 ± 2.1 |
| Fatigue at 150 (%) | - | - | 72.9 ± 1.8 | 76.4 ± 1.8 |
TTP—time to peak; HRT—half relaxation time.