Table 2.
Ex vivo measurement of soleus muscle force and fatigue. Fatigue was followed during 150 consecutive tetanus.
| TWITCH | TETANUS | |||
|---|---|---|---|---|
| TG2+/+ | TG2−/− | TG2+/+ | TG2−/− | |
| Number of animals | 8 | 7 | 8 | 7 |
| Number of muscles | 13 | 11 | 13 | 11 |
| Muscle weight (mg) | 18.32 ± 1.24 | 19.48 ± 1.31 | - | - |
| Force (mN/mm2) | 2.41 ± 0.28 | 1.49 ± 0.16 * | 12.18 ± 1.36 | 8.42 ± 0.66 * |
| TTP (ms) | 77.9 ± 3.8 | 77.1 ± 1.6 | 520.4 ± 1.4 | 522.9 ± 1.1 |
| HRT (ms) | 73.5 ± 5.6 | 72.4 ± 5.1 | 106.9 ± 3.8 | 105.7 ± 3.4 |
| Duration (ms) | 314.2 ± 24.4 | 301.4 ± 17.9 | 766.4 ± 10.0 | 771.5 ± 18.1 |
| Muscle venter area (mm2) | 1.02 ± 0.09 | 1.18 ± 0.08 | - | - |
| Fatigue at 50 (%) | - | - | 29.3 ± 0.5 | 38.4 ± 3.0 * |
| Fatigue at 100 (%) | - | - | 49.6 ± 0.6 | 60.7 ± 2.5 ** |
| Fatigue at 150 (%) | - | - | 57.5 ± 0.6 | 69.1 ± 2.9 ** |
* and ** show significant differences TG2+/+ at p < 0.05 and p < 0.01, respectively. TTP—time to peak; HRT—half relaxation time.