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. 2021 Nov 13;11(11):1199. doi: 10.3390/jpm11111199

Figure 3.

Figure 3

The association between the prognostic mitotic gene signature and gene mutations in hepatocellular carcinoma. (A) A waterfall plot shows the mRNA upregulation of the mitotic gene signature in HCC patients. (B) The prognostic impact of the mitotic gene signature expression on the overall survival of HCC patients. (C) The gene mutation frequency in HCC patients with high or low expression levels of mitotic gene signature. * indicates significant differences (p < 0.05) between two groups. (D) Upper: The genetic mutation statuses of TP53 and CTNNB1 genes in HCC patients. (D) Lower: The heat map for the mRNA expression levels of TP53, CTNNB1, and mitotic gene signature.