Figure 3.

Proposed depiction of endothelial dysfunction by ROS in respiratory virus-infected airways and potential therapeutic intervention. (A) Oxidative modification to the heterocyclic DNA base guanine(s) in gene regulatory sequences is considered an epigenetic mark that is recognized by the “reader” OGG1, leading assembly of transcriptional complex and dysregulated gene expression. Consequences are pulmonary edema, congestion, respiratory failure in patients with risk factor(s). (B) Inhibition of OGG1′ interaction with epigenetic mark decreases extent of inflammation and manifestation of endothelial dysfunction. TH5487, and SUO268, OGG1 specific inhibitors; BRD4, bromodomain-containing protein 4; CDK9, cyclin-dependent kinase 9; p50-p65, nuclear factor kappa B; CBP/p300, RNA pol II, RNA polymerase II.