. 2021 Nov 4;10(11):2378. doi: 10.3390/plants10112378

Table 3.

Combinatorial effects (FIC and FICI values) between Apiaceae essential oils/main constituents and terbinafine assessed by checkerboard method.

Combination	Trichophyton rubrum ATCC 28188			INT	Trichophyton mentagrophytes ATCC 9533			INT
Combination	MIC ^*_{in combination} (mg/L)	FIC	FICI	INT	MIC ^*_{in combination} (mg/L)	FIC	FICI	INT
Ajowan essential oil	16	0.06	0.31	S	16	0.06	0.56	Ad
Terbinafine	0.007	0.25	0.31	S	0.015	0.50	0.56	Ad
Coriander essential oil	8	0.01	0.26	S	32	0.06	0.56	Ad
Terbinafine	0.007	0.25	0.26	S	0.015	0.50	0.56	Ad
Caraway essential oil	16	0.03	0.28	S	64	0.12	0.62	Ad
Terbinafine	0.007	0.25	0.28	S	0.015	0.50	0.62	Ad
Anise essential oil	16	0.01	0.26	S	128	0.12	0.62	Ad
Terbinafine	0.007	0.25	0.26	S	0.015	0.50	0.62	Ad
Thymol	64	0.06	0.56	Ad	128	0.12	0.62	Ad
Terbinafine	0.015	0.5	0.56	Ad	0.015	0.5	0.62	Ad
Linalool	32	0.03	0.53	Ad	256	0.25	0.75	Ad
Terbinafine	0.015	0.5	0.53	Ad	0.015	0.5	0.75	Ad
Carvone	32	0.03	0.53	Ad	256	0.25	0.75	Ad
Terbinafine	0.015	0.5	0.53	Ad	0.015	0.5	0.75	Ad
Limonene	64	0.03	0.53	Ad	256	0.12	0.62	Ad
Terbinafine	0.015	0.5	0.53	Ad	0.015	0.5	0.62	Ad
Anethole	128	0.06	0.56	Ad	512	0.25	0.75	Ad
Terbinafine	0.015	0.5	0.56	Ad	0.015	0.5	0.75	Ad

Ad—addition; FIC—fractional inhibitory concentration; FICI—fractional inhibitory concentration index; INT—interpretation; S—synergism. * MIC of tested agent in most effective combination.