Table 1.
Virus and Formulation Type | Figures | Viral Production Process | Starting Infectivity Titer (IU/mL) | Starting Viral Particle Titer (VP/mL) | VP Assay Method |
---|---|---|---|---|---|
ChAdOx1 RVF, liquid | Figure 1A, Figure 2A,B and Figure 3A–D | No chromatography, inhouse | 1.5 × 109 | 2.1 × 1011 | qPCR, inhouse [24] |
ChAdOx2 RabG, liquid | Figure 1B and Figure 2A,B | With chromatography | 2.2 × 109 | 2.2 × 1011 | Spectrophotometry [25] |
ChAdOx1 RVF, liquid | Figure 2C | With chromatography | 2.3 × 109 | Not performed | Not performed |
ChAdOx2 RabG, liquid | Figure 2C | With chromatography | 2.20 × 109 | 2.2 × 1011 | Spectrophotometry [25] |
ChAdOx1 RVF for lyophilisation | Figure 4A,C,D | No chromatography, advent | 3.0 × 109 | 1.0 × 1011 | Proprietary qPCR |
ChAdOx2 RabG for lyophilisation | Figure 4B | With chromatography | 1.8 × 109 IU/mL | 1.3 × 1011 | Spectrophotometry [25] |