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. 2021 Oct 23;9(11):1427. doi: 10.3390/healthcare9111427

Table 3.

Characteristics of included studies.

First
Author and Year
Sample Size
(M/F)
Participant
Characteristics
Stand Density
(Trees/ha)
DBH
(cm)
Canopy Density Forest
Characteristics
Environmental
Characteristics
Outcome
Measurement
Activity Type Time of Measure Study
Design
An
2019
[84]
13
(7/6)
Healthy university students
Age: 21.8 ± 1.9
3 different forest sites
(no control assigned)
Location:
43°51′ N, 125°18′ E
Temp: 18 °C (10–25 °C)
Relative humidity: 45%
Wind speed: 3.33 m/s
SBP; DBP; HR Staying
(30 min)
Sep, 2017
(8:30–12:00)
Randomized Cross-over
1667/ha 13.26 0.56 Betula platyphylla Illuminance: 4617 lx SBP(/); DBP(/); HR(/)
1867/ha 10.35 0.75 Acer triflorum Illuminance: 1124 lx SBP(/); DBP(/); HR(+)
1993/ha 14.39 0.78 Quercus mongolica Illuminance: 1012 lx SBP(+/); DBP(+/); HR(+/)
Bach
2021
[85]
10
(6/4)
Healthy university students with no abnormalities in the respiratory or immune system
Age: 36.4 ± 6.5
One forest site and
urban site (control)
Location:
41°73 N, 2°44 E
Altitude:
860–972 m
Dominant species:
Quercus ilex
Temp: 23.87 ± 0.18 °C
Relative humidity: 53.7%
Blood concentration of Alpha-pinene(/); Beta-pinene(/); Alpha-phellandrene(/); Limonene(/); All monoterpene(/) Walking
(120 min)
July, 2018
(10:00–12:00)
Randomized Controlled
Trial
10500/ha 6.43 0.95
Bielinis
2019
[27]
21
(12/9)
Healthy university students and non-student volunteers with no mental or physical diseases or metabolic syndromes
Age: 23.9 ± 2.7
One forest group
(no control)
Location:
53°90 N, 20°35 E
Dominant species:
Picea abies and Pinus sylvestris
Temp: 25 °C
Relative humidity: 46%
Wind speed: 6.11 m/s
Noise: 38.08 ± 5.19 dB
Illuminance: 37755.24 lx
SBP(+); DBP(/); PR(+); MAP(+);
POMS(Confusion(+) Fatigue(+/) Anger(+) Anxiety(+) Depression(+) Vigor(/)); PANAS(PA(/) NA(+)); ROS(+); SVS(+)
Staying
(60 min)
May, 2018
(15:45–16:15)
Uncontrolled Before and After
1200/ha NA NA
Elsadek
2019
[86]
346
(200/164)
Healthy university students with no mental or physical diseases
Age: 23.0 ± 4.6
3 different forest sites and
urban site(control)
Location:
31°27 N, 121°46 E
POMS; STAI; ROS; SVS; PET Walking
(15 min)
May, 2018
(10:00–15:30)
Randomized
Crossover
NA NA 0.13 Urban road
(control)
Temp: 31.8 °C
Relative humidity: 42.8%
Wind speed: 0.66 m/s
POMS(Anxiety(−) Depression(−) Anger(−) Fatigue(−) Confusion(−) Vigor(−)); STAI(−); ROS(−); SVS(−)
0.49 Prunus serrulata Temp: 31.2 °C
Relative humidity: 47.0%
Wind speed: 0.23 m/s
POMS(Anxiety(+) Depression(+) Anger(+) Fatigue(+) Confusion(+) Vigor(+)); STAI(+); ROS(+); SVS(+)
0.89 Plantanus hispanica Temp: 29.0 °C
Relative humidity: 50.9%
Wind speed: 0.15m/s
POMS(Anxiety(+) Depression(+) Anger(+) Fatigue(+) Confusion(+) Vigor(+)); STAI(+); ROS(+); SVS(+)
0.94 Metasequoia glyptroboides Temp: 28.1 °C
Relative humidity: 52.9%
Wind speed: 0.11 m/s
POMS(Anxiety(+) Depression(+) Anger(+) Fatigue(+) Confusion(+) Vigor(+)); STAI(+); ROS(+); SVS(+)
Lee
2020
[87]
16
(5/11)
Housewives, freelancers and office workers
Age: 41.6 ± 1.8
One forest site and
one outdoor site(control)
Location:
35°83 N, 128°76 E
Dominant species:
Pinus rigida and Quercus aliena
NA DEP(+/); ANX(+/); AGG(/); ST-IN-S(+); ST-V-RG-P(+) Staying
(120 min)
May–Aug, 2017 Controlled Before and After
156/ha 27.4 NA
Oishi
2003
[88]
44
(23/21)
Healthy residents including students and workers
Age: 24.4 ± 9.9
5 different forest sites and one site outside the forest(control) Location:
39°75 N, 141°03 E
POMS Staying
(10 min)
Jul–Sep, 2001
(8:45–13:10)
Non-Randomized Cross-over
250/ha 23 NA Pinus densiflora Temp: 19.67 ± 3.31 °C
Relative humidity: 68.9%
POMS(Anxiety(+) Depression(+) Anger(+) Fatigue(+) Confusion(+) Vigor(+))
750/ha 34.9 Cyptomeria japonica Temp: 20.29 ± 3.66 °C
Relative humidity: 69.3%
POMS(Anxiety(+) Depression(+) Anger(+) Fatigue(+) Confusion(+) Vigor(+))
1700/ha 10.6 Quercus serrata Temp: 19.91 ± 3.40 °C
Relative humidity: 75.8%
POMS(Anxiety(+) Depression(+) Anger(+) Fatigue(+) Confusion(+) Vigor(+))
2275/ha 10.4 Pinus densiflora
Machilus thunbergii
Temp: 20.17 ± 3.19 °C
Relative humidity: 73.3%
POMS(Anxiety(+) Depression(+) Anger(+) Fatigue(+) Confusion(+) Vigor(+))
2875/ha 9.5 Pinus densiflora
Quercus serrata
Temp: 18.63 ± 3.16 °C
Relative humidity: 76.4%
POMS(Anxiety(+) Depression(+) Anger(+) Fatigue(+) Confusion(+) Vigor(+))
Saito
2019
[89]
17
(17/-)
healthy male volunteer had no history of cardiovascular disease or mental illness
Age: 40.2 ± 6.2
2 different forest sites:
managed forest and
unmanaged forest(control)
Location:
35°41 N, 138°86 E
Wind speed: m/s SBP; DBP; MAP; HR; HF; LF/HF; saliva cortisol Staying
(15 min)
July, 2014 Randomized Crossover
1024/ha 19.78 0.62 Mixed forest
(Broadleaf trees: 82% Coniferous trees: 18%)
Temp: 24.3 ± 2.8 °C
Relative humidity: 73.3%
Illuminance: 255.0 ± 97.6 lx
SBP(+); DBP(+); MAP(+); HR(/); HF(+/); LF/HF(+); saliva cortisol(+)
1208/ha 15.75 0.91 Mixed forest
(Broadleaf trees: 50% Coniferous trees: 50%)
Temp: 24.2 ± 2.8 °C
Relative humidity: 70.0%
Illuminance: 119.2 ± 48.5 lx
SBP(+); DBP(+); MAP(+); HR; HF(−/); LF/HF(−); saliva cortisol(+/)
Simkin
2020
[90]
66
(41/59)
City workers aged from 26–65
Age: 43.4 ± 10.7
4 different forest sites
(no control assigned)
Picea abies-dominated forests in Finland ROS; SVS; PANAS Staying
(15 min)
and
Walking
(45 min)
Aug–Oct, 2016
April–June, 2017
(15:00–17:00)
Randomized Crossover
374/ha 35 NA Location:
60°45 N, 25°19 E
(stand age > 120)
Temp: 12.8 ± 4.4 °C
Relative humidity:
39–96%
ROS(+); SVS(+); PANAS(+)
424/ha 30 Location:
60°22 N, 24°92 E
(stand age: 95)
Temp: 15.8 ± 4.2 °C
Relative humidity:
29–100%
ROS(+); SVS(+); PANAS(+)
520/ha 28 Location:
60°33 N, 25°18 E
(stand age: 100)
Temp: 15.9 ± 5.8 °C
Relative humidity:
39–91%
ROS(+); SVS(+); PANAS(+)
1746/ha 16 Location:
60°39 N, 25°18 E
(stand age: 40)
Temp: 15.3 ± 4.8 °C
Relative humidity:
27–98%
ROS(+); SVS(+); PANAS(+)
Takayama
2017a
[91]
18
(18/-)
Healthy male volunteer without history of cardiovascular disease or mental illness
Age: 40.2 ± 6.4
2 different forest sites:
managed forest and
unmanaged forest(control)
Location:
35°41 N, 138°86′ E
POMS; PANAS; ROS; PRS Staying
(15 min)
July, 2014 Randomized Crossover
1056/ha 23.12 0.62 Larix kaempferi 66%,
Cornus controversa 10% Pinus densiflora 7%
Temp: 24.3 ± 7.9 °C
Relative humidity: 73 ± 39%
Wind velocity:
0.13 m/s
Radiant Heat: 25.5 ± 10.5 °C
Illuminance: 255.0 ± 97.6 lx
Noise: 41.5 ± 3.8 dB
POMS(Anxiety(+) Depression(/) Anger(/) Fatigue(+/) Confusion(+) Vigor(+)); PANAS(PA(/)NA(+)); ROS(+)
1212/ha 18.54 0.91 Larix kaempferi 66%
Cornus controversa 7% Pinus densiflora 7%
Temp: 24.2 ± 7.6 °C
Relative humidity: 70 ± 34%
Wind velocity:
0.23 m/s
Radiant Heat: 25.3 ± 9.8 °C
Illuminance: 119.2 ± 48.5 lx
Noise: 39.0 ± 3.9 dB
POMS(Anxiety(+) Depression(/) Anger(/) Fatigue(/) Confusion(+) Vigor(+)); PANAS(PA(/)NA(+/)) ROS(/)
Takayama
2017
[92]
15
(11/4)
University students and mid-aged faculties without had no history of cardiovascular disease or mental illness
Age: 35.9 ± 8.2
2 different forest sites:
thinned forest and unthinned forest(control)
Location: 35°41′ N, 138°86′ E POMS; PANAS; ROS; PRS Staying
(15 min)
Oct,
May, 2013
Randomized Crossover
1056/ha 23.12 0.52 Larix kaempferi 66%,
Cornus controversa 10% Pinus densiflora 7%
Temp: 18.6 ± 0.92 °C
Relative humidity: 92 ± 4.6%
Wind velocity: 0.16 m/s
Radiant Heat: 18.8 ± 1.1 °C
Illuminance: 336 ± 172 lx
POMS(Anxiety(+) Depression(+) Anger(+) Fatigue(+/) Confusion(+) Vigor(/)); PANAS(PA(/)NA(/)) ROS(+/)
1200/ha 22.76 0.59 Larix kaempferi 66%,
Cornus controversa 10% Pinus densiflora 7%
Temp: 17.1 ± 2.52 °C
Relative humidity: 38 ± 20%
Wind velocity: 0.30  m/s
Radiant Heat: 21.8 ± 2.8 °C
Illuminance: 668 ± 237  lx
POMS(Anxiety(+) Depression(+) Anger(/) Fatigue(+) Confusion(+) Vigor(/)); PANAS(PA(/)NA(/)) ROS(+)
Yu
[93]
123
(43/85)
Middle-aged and elderly subjects aged 45 to 86 years No disease (n = 69), hypertension (n = 25), diabetes (n = 9), heart disease (n = 8)
Age: 60.0 ± 7.4
One forest site
(no control)
Location:
24°09 N, 121°18 E
Dominant species:
Cryptomeria japonica
Temp: 22.6 ± 1.4 °C
Relative humidity: 87.4%
Wind speed: 0.1 ± 0.2 m/s
PR(+); SBP(+); DBP(+); HF(/); LF/HF(/); POMS(Anxiety(+) Depression(+) Anger(+) Fatigue(+) Confusion(+) Vigor(+)); STAI(+) Walking
(180 min)
July, 2016
(8:30–12:00)
Uncontrolled Before and After
1200/ha NA NA
Zhou
2019
[94]
43
(8/35)
University students free from diagnosed cardiovascular, allergic, physical disease, or mental diseases
Age: 20.8 ± 0.9
2 different forest sites
(no control assigned)
Location:
26°11 N–26°55 N
106°07 E–107°17 E
Temp: 22.6 ± 1.4  °C
Relative humidity:
87.4%
Wind speed:
0.1 ± 0.2 m/s
Anti-anxiety scores walking (60 min) Dec, 2016 Randomized Cross-over
NA NA 0.20–0.75 Cinnamomum camphora
Quercus fabri
Platanus acerifolia
Anti-anxiety scores (financial states(+); exam pressure(+); campus life(/); love affair relationship(+))
0.50–0.75 Cinnamomum camphora
Celtis sinensis
Catalpa bungei
Celtis sinensis
Anti-anxiety scores(financial states(+); exam pressure(+); campus life(+); love affair relationship(/))

AGG 7—questions on aggression, ANX 11—questions on anxiety, DBP—diastolic blood pressure, DEP 11—questions on depression, HBP—high-frequency, HR—heart rate, LF/HF—ratio of low-frequency and high frequency, MAP—mean arterial pressure, PANAS—positive and negative affect schedule, POMS—profile of mood states, PR—pulse rate, PRS—perceived restorativeness scale, ROS—restorative outcomes scale, SBP—systolic blood pressure, STAI—state trait anxiety inventory, ST-V-IN-S—five questions on stress vulnerability-interpersonal sensitivity, ST-V-RG-P—five questions on stress vulnerability-self-regulation problems, SVS—subjective vitality scale, Temp—temperature. +: significant effect on positive health outcome; +/: including both significant and nonsignificant effect on positive health outcome; /: nonsignificant effect; -/: including both significant and nonsignificant effect on negative health outcome -: significant effect on negative outcome.