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. 2021 Nov 17;10(11):3206. doi: 10.3390/cells10113206

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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FXR relationship to glucocorticoid receptor function. There are complicated interactions between FXR and GC receptor in both their respective and synergistic responses to cellular insult. (A) Transcriptional response elements within the promoter sequence for glucocorticoid receptor RE—response element. (B) Synergistic anti-inflammatory relationship between FXR and GC receptor function such that diminishing activity of one affects functional response to injury of the other. OCA—obeticholic acid (C) GC receptor activation decreases functional effects of FXR; however, different mechanisms for this effect have been proposed. Additional relationship between FXR, GC receptor and COX activity have also been observed (CSE = cystathione-γ-lyase; SHP—small heterodimer protein, FGF-fibroblast growth factor) (Created with BioRender.com accessed on 10 October 2021).