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. 2021 Nov 11;22(22):12195. doi: 10.3390/ijms222212195

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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IGFBP2 controls platelet activation by SW620 cells. (A) The shRNA-mediated knockdown of IGFBP2 in SW620 cells was confirmed by Western blot, compared to nontargeted knockdown IGFBP2 Ctrl, and quantified by IGFBP2 ELISA using cell supernatants (left columns) and cell lysates (right columns) (B). (C) The knockdown of IGFBP2 in (MACC1-positive) SW620 cells restored the activation potential to platelets in the aggregation assay, or in ATP release (D). * p < 0.05; ** p < 0.01; *** p < 0.001.