Table 3.
Molecular characteristics associated with viral pathogenicity of H7 isolates.
| Virus † | Subtype | HA ‡ | PB2 | PB1 | PA | NA | M2 | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cleavage Site | 226 | 228 | 627 | 701 | 368 | 409 | Stalk del. | 274 | 292 | 31 | ||
| A/wDK/Kr/H296/2020 | H7N9 | PELPKGR/GLF | Q | G | E | D | I | S | No | H | R | S |
| A/wDK/Kr/H333/2020 | H7N8 | PELPKGR/GLF | Q | G | E | D | I | S | No | H | R | S |
| A/wDK/Kr/H42/2021 | H7N3 | PELPKGR/GLF | Q | G | E | D | I | S | No | H | R | S |
| A/mallard/Kr/H118/2021 | H7N9 | PELPKGR/GLF | Q | G | E | D | I | S | No | H | R | S |
| A/wDK/Kr/H214/2021 | H7N3 | PELPKRR/GLF | Q | G | E | D | I | S | No | H | R | S |
| A/DK/Cambodia/CAM08a/2019 | H7N6 | PELPKGR/GLF | Q | G | E | D | I | S | No | H | R | S |
| A/DK/Cambodia/CAM09a/2019 | H7N6 | PELPKGR/GLF | Q | G | E | D | I | S | No | H | R | S |
| A/Jiangsu/1/2018 | H7N4 | PELPKGR/GLF | Q | G | K | D | I | S | No | H | R | S |
| A/CK/Jiangsu/1/2018 | H7N4 | PELPKGR/GLF | Q | G | E | D | I | S | No | H | R | S |
| A/DK/Jiangsu/4/2018 | H7N4 | PELPKGR/GLF | Q | G | E | D | I | S | No | H | R | S |
| A/DK/Cambodia/12T-24-1-D3/2018 | H7N4 | PELPKGR/GLF | Q | G | E | D | I | S | No | H | R | S |
| A/DK/Cambodia/C50W8M1/2018 | H7N4 | PELPKGR/GLF | Q | G | E | D | I | S | No | H | R | S |
| A/Anhui/1/2013 | H7N9 | PEIPKGR/GLF | L | G | E | D | V | N | Yes | H | R | N |
| A/Shanghai/1/2013 | H7N9 | PEIPKGR/GLF | Q | G | E | D | I | N | Yes | H | R/K | N |
† wDK: wild duck; DK: duck; CK: chicken. ‡ H3 numbering was used. HA: hemagglutinin; PB: polymerase basic; PA: polymerase acidic; NA: neuraminidase; M: matrix.