|
Minimum Inhibitory Concentration (MIC in μg/mL) against Different Fungal Strains Evaluated
Candida Cryptococcus |
|||||||||
| Peptide Name | Sequence | C. krusei ATCC 6558 | C. parapsilosis ATCC 22019 |
C. albicans
SC5314 |
C. tropicalis
ATCC 750 |
C. albicans
ATCC 1453 |
C. glabrata
ATCC 2001 |
C. neoformans
H99 |
C. gattii
H0058-I-2029 |
| Act1 | KSKRWRKFEKRVKKIFEKTKEA-amide | 1.56 | 3.12 | >50 | 50 | >50 | 3.12 | 50 | 6.25 |
| Act2 | KSKRWRKFEKRVKKIFEKTKEAK-amide | 0.78 | 1.56 | >50 | 50 | >50 | 1.56 | 25 | 3.12 |
| Act2.1 | K(pS)KRWRKFEKRVKKIFEKTKEAK-amide (pS: phosphoserine) | 0.78 | 1.56 | >50 | >50 | >50 | 1.56 | >50 | 1.56 |
| Act2.2 | KSKRWRKFEKRVKKIFEKFKEAK-amide | 0.78 | 1.56 | >50 | 12.5 | >50 | 1.56 | 12.5 | 1.56 |
| Act3 | KSKRWRKFEKRVKKIFEHTKEA-amide | 0.78 | 3.12 | >50 | >50 | >50 | 1.56 | 50 | 3.12 |
| Act4 | KSKRWRKFEKRVKKIFEHTKEAK-amide | 0.78 | 1.56 | >50 | 50 | >50 | 3.12 | 50 | 1.56 |
| Act5 | GSKRWRKFEKRVKKIFEKTKEA-amide | 1.56 | 3.12 | 25–50 | >50 | >50 | 3.12 | 25 | 1.56 |
| Act6 | GSKRWRKFEKRVKKIFEKTKEAK-amide | 0.78 | 1.56 | >50 | >50 | >50 | 3.12 | 50 | 3.12 |
| Act7 | GSKRWRKFEKRVKKIFEHTKEA-amide | 0.78 | 1.56 | >50 | >50 | >50 | 3.12 | 50 | 3.12 |
| Act8 | GSKRWRKFEKRVKKIFEHTKEAK-amide | 0.78 | 1.56 | >50 | >50 | >50 | 3.12 | 50 | 3.12 |
| domcec | GSKRWRKFEKRVKK-amide | 3.12 | 3.12 | >50 | >50 | >50 | 6.25 | >50 | >50 |
| ConCec | GSKRWRKFEKRVKKIFEETKEALPVVQGVAGVAGAVGRR-amide | 0.78 | 0.39 | >50 | 25 | >50 | 1.56 | 25 | 1.56 |
| ox322 | GSKRWRKFEKRVKKVFEHTKEA-amide | 1.56 | 1.56 | >50 | >50 | >50 | 3.12 | 50 | 3.12 |
| sat122 | RSKKWRKIEKRVKKIFEKTKEA-amide | 1.56 | 0.39 | >50 | 50 | >50 | 3.12 | 50 | 3.12 |
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