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. 2021 Nov 17;22(22):12411. doi: 10.3390/ijms222212411

Figure 3.

Figure 3

Tregs and TH17s had similar activities in moderate and severe RA. (A) Levels of secreted IL-10 and IL-17 were measured in sera from patients with severe, moderate, low, and remission RA and healthy controls (n = 10 per group). Each symbol represents an individual donor. Statistical analysis among human subject groups was performed by one-way ANOVA, followed by Duncan’s post hoc test. Different letters (a, b) indicate statistically significant differences of cytokine levels among healthy control, patients in the remission, low, moderate, and severe RA groups (p < 0.05). (B,C) Proportions of Tregs/TH17 and their expression of ROS levels were measured in SFMCs (n = 5 per group). (D) Levels of IL-10 and IL-17 in synovial fluid from patients with moderate and severe RA were examined (n = 5 per group). (E) Proportions or MitoSOX levels of Tregs/TH17 were measured in paired samples of PBMCs and SFMCs from patients with severe RA (n = 2). Each symbol corresponds to one pair from the same donor. The bars in panels (A–D) represent the mean. n.s. = not significant.