Table 4.

Tabular description of all the selected eligible in vivo RCTs human studies of BMS, in terms of level of significance in subjective and objective assessments of pain, functionality improvement, anxiety reduction/QoL improvement and overall treatment satisfaction. Abbreviations: SS: Statistically significant; NSS: Not statistically significant; NI: No information. List of the abbreviations are listed in Supplementary File S2.

Study, Year, Origin and Citation	Primary Outcomes		Secondary Outcomes
	Pain/Burning Sensation Reduction		Functional Improvement	Anxiety/Depression and QoL		Overall Treatment Satisfaction
	Qualitative (Subjective) VAS, NSP, PPI (SS, NSS, NI)	Quantitative (Objective) MPQ (SS, NSS, NI)	Quantitative (Objective) Salivary analysis Profile Microcirculation Assessment Immuno-Histochemistry Analysis (SS, NSS, NI)	Qualitative (Subjective) BAI, PAD, HRQL, OHIP (SS, NSS, NI)	Quantitative (Objective) HADS, SCL-90-R, Euro Qol-5D 5L, GDS, SF-36 (SS, NSS, NI)	Quantitative (Objective) PGI-I (SS, NSS, NI)
Bardellini et al., 2019 (Italy) [74]	SS	NI	NI	SS	NI	NI
Valenzuela et al., 2017 (Spain) [75]	SS	NI	NSS	SS	NSS	NSS
Arbabi-Kalati et al., 2015 [76]	SS	NI	NI	SS	NI	NI
Arduino et al., 2016 (Italy) [77]	SS	SS	SS	NI	SS	NI
Sugaya et al., 2016 (Brazil) [78]	SS	NI	NI	NI	NI	SS
Spanemberg et al., 2015 (Spain) [79]	SS	NI	NI	SS	NI	NI
Skrinjar et al., 2020 (Croatia) [80]	NSS	NI	NSS	NI	NI	NI
Pezelj-Ribarić et al., 2013 (Croatia) [81]	NSS	NI	NSS	NI	NI	NI
Sikora et al., 2018 (Croatia) [82]	NSS	NI	NI	NSS	NI	NI
Spanemberg et al., 2019 (Spain) [83]	SS	NI	NI	NI	SS	NI
De Pedro et al., 2020 (Spain) [84]	SS	SS	NI	SS	SS	NI
Scardina et al., 2020 (Italy) [85]	NSS	NI	NSS	NI	NI	NI