Table 7.
The quantities of theophylline which can be dissolved in HPMC at a given temperature.
| Temperature (°C) | 0 | 10 | 20 | 30 | 40 | 50 | 60 | 70 | 80 | 90 | 100 | 110 | 120 | 130 | 140 | 150 | 160 | 170 | 180 | 190 | 200 | 210 | 220 | 230 | 240 | 250 | 260 | 270 | 
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Theophylline (%) | Theophylline Dissolved in HPMC at a Given Temperature (%) | |||||||||||||||||||||||||||
| 2 | 0.06 | 0.09 | 0.15 | 0.22 | 0.32 | 0.45 | 0.62 | 0.85 | 1.14 | 1.50 | 1.95 | |||||||||||||||||
| 3 | 0.06 | 0.10 | 0.15 | 0.22 | 0.32 | 0.45 | 0.63 | 0.86 | 1.15 | 1.51 | 1.97 | 2.52 | ||||||||||||||||
| 4 | 0.06 | 0.10 | 0.15 | 0.22 | 0.32 | 0.46 | 0.64 | 0.87 | 1.16 | 1.53 | 1.99 | 2.55 | 3.22 | |||||||||||||||
| 5 | 0.06 | 0.10 | 0.15 | 0.22 | 0.33 | 0.46 | 0.64 | 0.88 | 1.17 | 1.55 | 2.01 | 2.57 | 3.26 | 4.07 | ||||||||||||||
| 6 | 0.06 | 0.10 | 0.15 | 0.23 | 0.33 | 0.47 | 0.65 | 0.89 | 1.19 | 1.56 | 2.03 | 2.60 | 3.29 | 4.11 | 5.08 | |||||||||||||
| 7 | 0.06 | 0.10 | 0.15 | 0.23 | 0.33 | 0.47 | 0.66 | 0.90 | 1.20 | 1.58 | 2.05 | 2.63 | 3.32 | 4.15 | 5.14 | 6.29 | ||||||||||||
| 8 | 0.06 | 0.10 | 0.16 | 0.23 | 0.34 | 0.48 | 0.67 | 0.91 | 1.21 | 1.60 | 2.08 | 2.66 | 3.36 | 4.20 | 5.19 | 6.35 | 7.70 | |||||||||||
| 9 | 0.07 | 0.10 | 0.16 | 0.24 | 0.34 | 0.49 | 0.67 | 0.92 | 1.23 | 1.62 | 2.10 | 2.69 | 3.39 | 4.24 | 5.24 | 6.42 | 7.78 | |||||||||||
| 10 | 0.07 | 0.11 | 0.16 | 0.24 | 0.35 | 0.49 | 0.68 | 0.93 | 1.24 | 1.63 | 2.12 | 2.71 | 3.43 | 4.29 | 5.30 | 6.48 | 7.86 | 9.44 | ||||||||||
| 11 | 0.07 | 0.11 | 0.16 | 0.24 | 0.35 | 0.50 | 0.69 | 0.94 | 1.26 | 1.65 | 2.14 | 2.74 | 3.47 | 4.33 | 5.35 | 6.55 | 7.94 | 9.54 | ||||||||||
| 12 | 0.07 | 0.11 | 0.16 | 0.24 | 0.36 | 0.50 | 0.70 | 0.95 | 1.27 | 1.67 | 2.17 | 2.77 | 3.50 | 4.38 | 5.41 | 6.61 | 8.02 | 9.63 | 11.48 | |||||||||
| 13 | 0.07 | 0.11 | 0.17 | 0.25 | 0.36 | 0.51 | 0.71 | 0.96 | 1.28 | 1.69 | 2.19 | 2.80 | 3.54 | 4.42 | 5.46 | 6.68 | 8.10 | 9.73 | 11.59 | |||||||||
| 14 | 0.07 | 0.11 | 0.17 | 0.25 | 0.36 | 0.51 | 0.71 | 0.97 | 1.30 | 1.71 | 2.22 | 2.83 | 3.58 | 4.47 | 5.52 | 6.75 | 8.18 | 9.83 | 11.71 | 13.84 | ||||||||
| 15 | 0.07 | 0.11 | 0.17 | 0.25 | 0.37 | 0.52 | 0.72 | 0.98 | 1.31 | 1.73 | 2.24 | 2.86 | 3.62 | 4.52 | 5.58 | 6.82 | 8.26 | 9.92 | 11.82 | 13.98 | ||||||||
| 16 | 0.07 | 0.11 | 0.17 | 0.26 | 0.37 | 0.53 | 0.73 | 0.99 | 1.33 | 1.75 | 2.26 | 2.89 | 3.66 | 4.56 | 5.64 | 6.89 | 8.35 | 10.02 | 11.94 | 14.12 | ||||||||
| 17 | 0.07 | 0.11 | 0.18 | 0.26 | 0.38 | 0.53 | 0.74 | 1.01 | 1.34 | 1.77 | 2.29 | 2.93 | 3.69 | 4.61 | 5.69 | 6.96 | 8.43 | 10.13 | 12.06 | 14.26 | 16.74 | |||||||
| 18 | 0.07 | 0.12 | 0.18 | 0.26 | 0.38 | 0.54 | 0.75 | 1.02 | 1.36 | 1.79 | 2.31 | 2.96 | 3.73 | 4.66 | 5.75 | 7.03 | 8.52 | 10.23 | 12.18 | 14.40 | 16.90 | |||||||
| 19 | 0.07 | 0.12 | 0.18 | 0.27 | 0.39 | 0.55 | 0.76 | 1.03 | 1.37 | 1.81 | 2.34 | 2.99 | 3.77 | 4.71 | 5.81 | 7.11 | 8.61 | 10.33 | 12.30 | 14.54 | 17.07 | |||||||
| 20 | 0.08 | 0.12 | 0.18 | 0.27 | 0.39 | 0.55 | 0.77 | 1.04 | 1.39 | 1.83 | 2.37 | 3.02 | 3.82 | 4.76 | 5.88 | 7.18 | 8.69 | 10.44 | 12.43 | 14.69 | 17.23 | |||||||
| 25 | 0.08 | 0.13 | 0.19 | 0.29 | 0.42 | 0.59 | 0.81 | 1.10 | 1.47 | 1.93 | 2.50 | 3.19 | 4.03 | 5.02 | 6.19 | 7.56 | 9.15 | 10.98 | 13.07 | 15.44 | 18.10 | 21.10 | ||||||
| 30 | 0.09 | 0.14 | 0.21 | 0.31 | 0.44 | 0.62 | 0.86 | 1.17 | 1.56 | 2.04 | 2.64 | 3.37 | 4.25 | 5.29 | 6.53 | 7.97 | 9.64 | 11.55 | 13.74 | 16.23 | 19.03 | 22.16 | 25.65 | |||||
| 35 | 0.09 | 0.14 | 0.22 | 0.32 | 0.47 | 0.66 | 0.91 | 1.24 | 1.65 | 2.16 | 2.79 | 3.56 | 4.49 | 5.59 | 6.88 | 8.40 | 10.15 | 12.16 | 14.46 | 17.07 | 20.00 | 23.29 | 26.95 | 31.00 | ||||
| 40 | 0.10 | 0.15 | 0.23 | 0.35 | 0.50 | 0.70 | 0.97 | 1.31 | 1.74 | 2.29 | 2.95 | 3.76 | 4.74 | 5.90 | 7.26 | 8.85 | 10.69 | 12.81 | 15.23 | 17.96 | 21.04 | 24.48 | 28.32 | 32.56 | 37.24 | |||
| 45 | 0.11 | 0.16 | 0.25 | 0.37 | 0.53 | 0.74 | 1.03 | 1.39 | 1.85 | 2.42 | 3.12 | 3.98 | 5.00 | 6.22 | 7.66 | 9.33 | 11.27 | 13.50 | 16.03 | 18.90 | 22.13 | 25.75 | 29.77 | 34.22 | 39.12 | |||
| 50 | 0.11 | 0.17 | 0.27 | 0.39 | 0.56 | 0.79 | 1.09 | 1.47 | 1.96 | 2.56 | 3.30 | 4.20 | 5.28 | 6.57 | 8.08 | 9.84 | 11.88 | 14.22 | 16.88 | 19.90 | 23.29 | 27.09 | 31.30 | 35.97 | 41.11 | 46.75 | ||
| 55 | 0.12 | 0.19 | 0.28 | 0.42 | 0.60 | 0.84 | 1.15 | 1.56 | 2.07 | 2.71 | 3.49 | 4.44 | 5.58 | 6.94 | 8.53 | 10.38 | 12.53 | 14.99 | 17.79 | 20.95 | 24.52 | 28.50 | 32.93 | 37.83 | 43.22 | 49.13 | ||
| 60 | 0.13 | 0.20 | 0.30 | 0.44 | 0.63 | 0.89 | 1.22 | 1.65 | 2.19 | 2.87 | 3.69 | 4.69 | 5.90 | 7.32 | 9.00 | 10.95 | 13.21 | 15.79 | 18.74 | 22.07 | 25.81 | 29.99 | 34.64 | 39.78 | 45.44 | 51.64 | ||
| 65 | 0.14 | 0.21 | 0.32 | 0.47 | 0.67 | 0.94 | 1.30 | 1.75 | 2.32 | 3.03 | 3.90 | 4.96 | 6.23 | 7.73 | 9.49 | 11.55 | 13.92 | 16.65 | 19.74 | 23.24 | 27.18 | 31.57 | 36.45 | 41.85 | 47.79 | 54.29 | 61.39 | |
| 70 | 0.14 | 0.22 | 0.34 | 0.50 | 0.71 | 1.00 | 1.37 | 1.85 | 2.45 | 3.20 | 4.12 | 5.24 | 6.57 | 8.16 | 10.02 | 12.18 | 14.68 | 17.54 | 20.80 | 24.48 | 28.61 | 33.23 | 38.36 | 44.03 | 50.26 | 57.09 | 64.54 | |
| 75 | 0.15 | 0.24 | 0.36 | 0.53 | 0.75 | 1.06 | 1.45 | 1.96 | 2.60 | 3.39 | 4.36 | 5.53 | 6.94 | 8.61 | 10.57 | 12.84 | 15.47 | 18.49 | 21.91 | 25.78 | 30.13 | 34.98 | 40.37 | 46.32 | 52.87 | 60.04 | 67.86 | |
| 80 | 0.16 | 0.25 | 0.38 | 0.56 | 0.80 | 1.12 | 1.54 | 2.07 | 2.74 | 3.58 | 4.60 | 5.84 | 7.32 | 9.08 | 11.14 | 13.54 | 16.30 | 19.47 | 23.08 | 27.15 | 31.72 | 36.82 | 42.48 | 48.73 | 55.61 | 63.14 | 71.35 | |
| 85 | 0.17 | 0.27 | 0.40 | 0.59 | 0.84 | 1.18 | 1.62 | 2.18 | 2.89 | 3.77 | 4.85 | 6.16 | 7.72 | 9.57 | 11.74 | 14.26 | 17.17 | 20.51 | 24.29 | 28.57 | 33.38 | 38.74 | 44.69 | 51.26 | 58.49 | 66.40 | 75.02 | |
| 90 | 0.18 | 0.28 | 0.42 | 0.62 | 0.89 | 1.25 | 1.71 | 2.30 | 3.05 | 3.98 | 5.11 | 6.49 | 8.13 | 10.08 | 12.36 | 15.01 | 18.08 | 21.58 | 25.57 | 30.06 | 35.11 | 40.75 | 47.00 | 53.91 | 61.50 | 69.81 | 78.87 | 88.70 | 
| 95 | 0.19 | 0.30 | 0.45 | 0.66 | 0.94 | 1.31 | 1.80 | 2.43 | 3.21 | 4.19 | 5.38 | 6.83 | 8.55 | 10.60 | 13.00 | 15.79 | 19.01 | 22.70 | 20.81 | 31.61 | 36.92 | 42.84 | 49.41 | 56.67 | 64.65 | 73.38 | 82.89 | 93.22 |