Figure 4.

Structural analysis of the pocket associated with cluster 5 across the three KIM-PTPs (HePTP, PTPSL and STEP). In the top panels the three KIM-PTPs are represented as surfaces, whilst in the bottom panels they are shown in cartoon format, with key residues shown as sticks and labelled accordingly. In both panels the colouring is as follows: KIM-PTP specific motifs K5 (magenta), K6 (cyan), and K7 (blue). In the bottom panel the difference in the conformation of the loop that forms the lip at the bottom entrance of the pocket is also coloured as follows: HePTP (orange), PTPSL (red), and STEP (yellow) to aid visualisation.