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. 2021 Nov 20;10(11):3252. doi: 10.3390/cells10113252

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Crosstalk of LSD1 with DNA methylation. (A) DNMT1 and UHRF1 are methyltransferases involved in the maintenance of DNA methylation. LSD1 can demethylate DNMT1 and UHRF1 at the positions K1096 and K385, respectively, preventing proteasome-mediated degradation and subsequent hypomethylation of the DNA. (B) LSD1-mediated demethylation of H3K4me1 at pluripotent enhancers promotes the deposition of 5mC by DNMT3A-DNMT3L, repressing the expression of pluripotency factors during differentiation. In stem cells, H3K27ac inhibits the methyltransferase activity of the DNMT3A-DNMT3L complex.