Figure 4.

Schematic representation of the versatility of our microfluidic platform to study protein therapies and nanomedicines in various organ-on-a-chip systems. (A) Schematic with different parameters that can be included or modified in the microfluidic platform to mimic organ physiology and drug delivery. (B) Schematic of a microfluidic chip with drug delivery from both side channels as in the tumor-on-a-chip implementation utilized in this study to deliver anti-CAIX affibodies to tumor cells. (C) Alternative use of the microfluidic platform for mimicking the physiology of compartmentalized organ substructures from the kidney or bladder or the lymphatic drainage present in some tumors. (D) Schematic of the microfluidic chip with addition of only medium in the side channels, as studied in this paper, to mimic a bone-on-a-chip.