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. 2021 Nov 7;11(11):1156. doi: 10.3390/jpm11111156

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Kaplan–Meier Curves. In this cohort, patients with circulating tumor cell (CTC) numbers >=3 cells/mL had shown to negatively impact progression-free survival (PFS, p = 0.002) (A). Patients are associated with prolonged PFS, for those with p16-positive CTC (p = 0.012) (B), disease control after concurrent chemoradiotherapy was carried out (CCRT, p < 0.001) (C). However, tissue p16 expression is only marginally significant to PFS (p = 0.089) (D). For overall survival (OS), a prolonged OS is associated with patients harboring a CTC count of <3 cells/mL (p = 0.022) (E), p16 positivity of CTCs (p = 0.017) (F), and disease control after CCRT (p = 0.003) (G). Nevertheless, tissue p16 expression has no significant impact on OS in this cohort (p = 0.365) (H).

Kaplan–Meier Curves. In this cohort, patients with circulating tumor cell (CTC) numbers >=3 cells/mL had shown to negatively impact progression-free survival (PFS, p = 0.002) (A). Patients are associated with prolonged PFS, for those with p16-positive CTC (p = 0.012) (B), disease control after concurrent chemoradiotherapy was carried out (CCRT, p < 0.001) (C). However, tissue p16 expression is only marginally significant to PFS (p = 0.089) (D). For overall survival (OS), a prolonged OS is associated with patients harboring a CTC count of <3 cells/mL (p = 0.022) (E), p16 positivity of CTCs (p = 0.017) (F), and disease control after CCRT (p = 0.003) (G). Nevertheless, tissue p16 expression has no significant impact on OS in this cohort (p = 0.365) (H).