Table 2.
Predicted HTL epitopes. The table shows the specific allele against which the HTL epitopes are predicted. Furthermore, it also shows the methods and percentile rank of each peptide. The HTL epitopes shown in bold are the finally selected epitopes for multi-epitopes vaccine construct.
| S. No. | Allele | Start | End | Peptide Sequence | Method | Percentile Rank |
|---|---|---|---|---|---|---|
| 1 | HLA-DRB1*07:01 | 73 | 87 | AALRKIKRTVSALMV | Consensus (comb.lib./smm/nn) | 0.03 |
| 2 | HLA-DRB1*07:01 | 72 | 86 | TAALRKIKRTVSALM | Consensus (comb.lib./smm/nn) | 0.04 |
| 3 | HLA-DRB1*07:01 | 74 | 88 | ALRKIKRTVSALMVG | Consensus (comb.lib./smm/nn) | 0.06 |
| 4 | HLA-DRB1*07:01 | 75 | 89 | LRKIKRTVSALMVGL | Consensus (comb.lib./smm/nn) | 0.06 |
| 5 | HLA-DRB1*07:01 | 76 | 90 | RKIKRTVSALMVGLQ | Consensus (comb.lib./smm/nn) | 0.06 |
| 6 | HLA-DRB5*01:01 | 65 | 79 | SVPLKQATAALRKIK | Consensus (smm/nn/sturniolo) | 0.08 |
| 7 | HLA-DRB5*01:01 | 66 | 80 | VPLKQATAALRKIKR | Consensus (smm/nn/sturniolo) | 0.08 |
| 8 | HLA-DRB1*07:01 | 77 | 91 | KIKRTVSALMVGLQK | Consensus (comb.lib./smm/nn) | 0.13 |
| 9 | HLA-DRB5*01:01 | 64 | 78 | NSVPLKQATAALRKI | Consensus (smm/nn/sturniolo) | 0.14 |
| 10 | HLA-DRB5*01:01 | 63 | 77 | WNSVPLKQATAALRK | Consensus (smm/nn/sturniolo) | 0.43 |
| 11 | HLA-DRB1*15:01 | 35 | 49 | NGLVLMRMMGILWHA | Consensus (smm/nn/sturniolo) | 0.72 |
| 12 | HLA-DRB1*15:01 | 33 | 47 | MPNGLVLMRMMGILW | Consensus (smm/nn/sturniolo) | 0.73 |
| 13 | HLA-DRB1*15:01 | 34 | 48 | PNGLVLMRMMGILWH | Consensus (smm/nn/sturniolo) | 0.73 |
| 14 | HLA-DRB5*01:01 | 68 | 82 | LKQATAALRKIKRTV | Consensus (smm/nn/sturniolo) | 0.75 |
| 15 | HLA-DRB5*01:01 | 67 | 81 | PLKQATAALRKIKRT | Consensus (smm/nn/sturniolo) | 0.81 |
| 16 | HLA-DRB1*15:01 | 36 | 50 | GLVLMRMMGILWHAV | Consensus (smm/nn/sturniolo) | 0.88 |
| 17 | HLA-DRB1*15:01 | 37 | 51 | LVLMRMMGILWHAVA | Consensus (smm/nn/sturniolo) | 0.93 |