Table 3.

Comparison of diagnostic performance of US, CEUS, and US + CEUS for SLN status.

Methods	Sen	Spe	PPV	NPV	AUC (95% CI)
US *,#	70.67% (53/75)	77.68% (87/112)	67.95% (53/78)	79.82% (87/109)	0.742 (0.677–0.806)
CEUS &	82.67% (62/75)	80.36% (90/112)	73.81% (62/84)	87.38% (90/103)	0.815 (0.758–0.872)
US + CEUS	86.67% (65/75)	77.68% (87/112)	72.22% (65/90)	89.69% (87/97)	0.822 (0.767–0.876)

SLN = Sentinel lymph node, US = Ultrasound, CEUS = Contrast-enhanced ultrasound, Sen = Sensitivity, Spe = Specificity, PPV = Positive predictive value, NPV = Negative predictive value, AUC = area under the curve, CI = Confidence interval. Note: * indicates p = 0.005 compared with the CEUS group; ^# indicates p < 0.001 compared with the CEUS + US group; ^& indicates p = 0.630 compared with the US + CEUS group.