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. 2021 Nov 9;22(22):12134. doi: 10.3390/ijms222212134

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Xanthohumol inhibited hydrolase activities of SARS-CoV-2 M^pro in a dose-dependent manner. (A) Relative enzyme activities of SARS-CoV-2 M^pro in the presence of 10 μM compounds. (B) The kinetic curves in the presence of Xanthohumol, MG132, and the solvent, DMSO. Xanthohumol and MG132 were added to the final concentration of 20 μM. (C) Xanthohumol inhibited M^pro dose-dependently. (D) The IC₅₀ value of Xanthohumol. (E) The Ki value of Xanthohumol on SARS-CoV-2 M^pro. Data are shown as means ± standard error of mean (SEM) from three independent experiments.