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. 2021 Nov 24;221(2):e202107070. doi: 10.1083/jcb.202107070

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© 2021 Crosby et al.

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Figure 9. — The neuronal ATL2-2 splice variant lacks C-terminal autoinhibition. (A) Alignment of C-terminal extensions of ATL2-1 and ATL2-2. Isoform 2 contains arginine residues (underlined) in the identical location as glutamic acid residues (E555 and E556) of isoform 1 (Fig. 6). AH, amphipathic helix. (B) Lipid mixing performed after reconstitution of each isoform at 1:1,000 protein/lipid ratio. The data are the average of at least two individual traces. (C) RT-PCR from total RNA showing ATL2-1 and ATL2-2 expression in human liver and brain.