Table 5.
Prognostic factors for poor visual outcome [defined as corrected-distance-visual-acuity (CDVA) of <1.0 logMAR]. and poor corneal healing (defined as >60 days to achieve complete healing or required tectonic/therapeutic keratoplasty, evisceration or enucleation) in fungal keratitis in the UK.
| Poor Visual Outcome | Poor Corneal Healing | |||
|---|---|---|---|---|
| Parameters | Odd Ratio (95% CI) | p-Value * | Odd Ratio (95% CI) | p-Value * |
| Age > 50 years | 4.72 (1.40–15.89) | 0.012 | 5.81 (1.83–18.37) | 0.003 |
| Male gender | 0.99 (0.33–3.00) | 0.99 | 0.93 (0.33–2.72) | 0.91 |
| Right eye | 1.13 (0.37–3.43) | 0.83 | 2.86 (0.95–8.61) | 0.06 |
| Presenting CDVA < 1.0 | 14.92 (4.19–53.18) | <0.001 | 3.91 (1.19–12.82) | 0.025 |
| Infiltrate size > 3 mm | 3.61 (1.11–11.81) | 0.034 | 3.91 (1.18–12.88) | 0.025 |
| Central ulcer | 1.51 (0.50–4.53) | 0.47 | 1.58 (0.55–4.58) | 0.4 |
| Presence of hypopyon | 2.87 (0.81–10.18) | 0.1 | 2.78 (0.78–9.86) | 0.12 |
| Culture results | 0.88 | 0.44 | ||
| Negative | Reference | - | Reference | - |
| Yeast | 1.36 (0.37–4.97) | 0.64 | 1.67 (0.49–5.76) | 0.42 |
| Filamentous | 0.95 (0.19–4.71) | 0.95 | 2.74 (0.52–14.41) | 0.23 |
| Co-infection with bacteria | 1.70 (0.49–5.93) | 0.4 | 0.71 (0.23–2.26) | 0.57 |
* Multivariable logistic regression analysis was performed. Significant p-values are underlined.