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. 2021 Nov 18;22(22):12457. doi: 10.3390/ijms222212457

Figure 6.

Figure 6

The effect of PLX5622 on the expression of immune modulators in brains of infected mice. Brains of infected mice fed with control chow or the chow containing PLX5622 were harvested, processed, and assayed by ELISA (A,B) and quantitative RT-PCR (C,D). The levels of (A) IFN-γ on day 7 post-infection and (B) IFN-β on the indicated days post-infection are shown. The mRNA levels of (C) IFN-stimulated genes (ISGs) and (D) pro-inflammatory as well as anti-inflammatory modulators on day 5 post-infection are shown. In panels (C,D), the data are expressed as the ratio of indicated mRNA normalized to β-actin mRNA, and the means of control groups were set as 1. The data represent means + SEM (error bars) of 4–5 samples per group. *, p < 0.05.