Table 2.
Coagulation parameters in relation to major clinical features and mortality of IE patients.
| D-Dimers | p-Value | Fibrinogen | p-Value | PT-INR | p-Value | aPTT | p-Value | PlateletCount | p-Value | Homocysteine | p-Value | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gender: | 0.246 | 0.775 | 0.058 | 0.741 | 0.728 | 0.357 | ||||||
| Male | 566 (280–1086) | 402 (313–536) | 1.30 (1.15–1.50) | 32.6 (30–38.1) | 205 (150–262) | 15 (12–20) | ||||||
| Female | 673 (345–1167) | 433 (332–532) | 1.40 (1.20–2.17) | 32.5 (29.4–37.8) | 200 (137–269) | 14 (12–19) | ||||||
| Age: | 0.047 | 0.099 | 0.270 | 0.729 | 0.001 | 0.003 | ||||||
| ≤64 | 558 (257–1015) | 417 (333–567) | 1.30 (1.14–1.50) | 32.7 (29.2–37.8) | 215 (162–285) | 14 (11–18.5) | ||||||
| >64 | 633 (358–1217) | 390 (300–501) | 1.30 (1.19–1.82) | 32.5 (29.6–38.4) | 190 (131–239) | 16 (13–22) | ||||||
| Embolic event: | <0.001 | 0.134 | 0.473 | <0.001 | 0.150 | 0.366 | ||||||
| No | 512 (237–995) | 402 (306–515) | 1.30 (1.17–1.80) | 33.7 (30.6–38.9) | 204 (146–258) | 15 (12–20) | ||||||
| Yes | 765 (532–1592) | 446 (338–585) | 1.30 (1.18–1.50) | 30.6 (28.4–34.8) | 203 (153–286) | 14.3 (11.7–18.1) | ||||||
| Surgery indication: | 0.309 | 0.595 | <0.001 | 0.266 | 0.917 | 0.840 | ||||||
| No | 525 (310–1027) | 433 (364–504) | 1.41 (1.21–2.35) | 33.7 (29.6–39) | 206 (150–261) | 15.2 (12–19) | ||||||
| Yes | 617 (296–1167) | 399 (308–555) | 1.29 (1.12–1.50) | 32.1 (29.6–37.3) | 203(148–265) | 14.5 (12–20) | ||||||
| Surgery performed: | 0.164 | 0.252 | <0.001 | 0.230 | 0.782 | 0.523 | ||||||
| No | 525 (286–965) | 424 (331–555) | 1.40 (1.20–2.20) | 33.7 (29.1–39.1) | 204 (151–261) | 15.1 (12–19) | ||||||
| Yes | 627 (312–1196) | 397 (302–528) | 1.29 (1.12–1.50) | 32.1 (29.9–37.3) | 203 (147–266) | 14.2(11.4–20.2) | ||||||
| Hospitalization outcome: | 0.012 | 0.933 | 0.013 | 0.090 | 0.398 | 0.886 | ||||||
| Alive | 582 (274–1041) | 407 (324–535) | 1.30 (1.15–1.70) | 32.3 (29.6–37.8) | 204 (152–262) | 15 (12–20) | ||||||
| Dead | 869 (498–1927) | 419 (299–527) | 1.50 (1.22–2.6) | 36.6 (31.5–43) | 201 (103–279) | 15 (12–22) | ||||||
| 1-year outcome: | 0.390 | 0.821 | 0.078 | 0.021 | 0.275 | 0.059 | ||||||
| Alive | 567 (315–1028) | 424 (331–56) | 1.30 (1.15–1.60) | 32.3 (30.1–37.6) | 209 (154–275) | 14.2 (11.4–19) | ||||||
| Dead | 667 (290–1326) | 438 (322–546) | 1.30 (1.20–2.28) | 36.6 (31.5–44) | 201 (143–266) | 16 (12–22) |
Data are median (IQR); p-value was generated by Mann–Whitney U test; 246 surgery indication–208 surgery performed. Abbreviations: aPTT: activated partial thromboplastin time; PT-INR: prothrombin time international normalized ratio. Statistically significant results are marked in bold.