Table 2.
Summary statistics of novel loci. Per locus, we report the strongest association statistics for the best-associated variant. In parenthesis, we report analysis groups showing genome-wide significance (a, all; m, males; f, females). The analysis group showing the strongest significance is displayed in bold. Abbreviation: E/OA, effect/other allele; EAF, effect allele frequency (mean of LIFE-Adult and LIFE-Heart); Info, imputation info-score (minimum of LIFE-Adult and LIFE-Heart); IA-FDR, adjusted p-value of interaction test, marked in bold if significant. See supplementary material for justification of proposed candidate genes.
| Cytoband | Lead SNP | Nearest Gene (kb) | Candidate Gene (kb) | E/OA | EAF | Info | Associated Phenotypes | β (SE) | p Value | I2 | IA-FDR |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1q32.2 | rs138621610 | C1orf132 (0) | CD55 (445) | A/G | 0.010 | 0.983 | P4 (a, f) | 0.708 (0.128) | 3.27 × 10−08 | 0 | 4.97 × 10−6 |
| 7q36.3 | rs2467806 | VIPR2 (0) | VIPR2 (0) | C/T | 0.989 | 0.862 | P4 (a, m, f) | −0.373 (0.068) | 3.85 × 10−08 | 0.892 | 1.87 × 10−2 |
| 16p13.3 | rs144711998 | RBFOX1 (0) | RBFOX1 (0) | T/C | 0.025 | 0.879 | P4 (a, f) | 0.525 (0.095) | 3.30 × 10−08 | 0 | 3.13 × 10−6 |
| 1p12 | rs947130 | HSD3BP1 (0.31) | HSD3B1 (33) | C/T | 0.731 | 0.922 | 17-OHP (a, m) | 0.112 (0.017) | 1.03 × 10−10 | 0 | 5.14 × 10−4 |
| 2p15 | rs17014577 | FAM161A (0) | REL (913) | C/T | 0.143 | 0.991 | 17-OHP (a, m) | 0.113 (0.021) | 4.49 × 10−08 | 0 | 7.81 × 10−2 |
| 18q22.3 | rs1430542 | RN7SL401P (64) | CYB5A (442) | C/T | 0.724 | 0.924 | 17-OHP (a, f) | −0.166 (0.028) | 6.21 × 10−09 | 0 | 8.21 × 10−7 |
| 10q26.3 | rs11311009 | MGMT (0) | MGMT (0) | C/CT | 0.419 | 0.980 | A4 (a, m) | 0.064 (0.012) | 3.78 × 10−08 | 0.367 | 7.06 × 10−4 |
| 1q23.3 | chr1:162778017 | HSD17B7 (0) | HSD17B7 (0) | A/C | 0.015 | 0.969 | Aldo (a, f) | 0.565 (0.097) | 5.70 × 10−9 | 0.415 | 9.62 × 10−6 |
| 14q31.2 | rs117866409 | Gene desert | CNST (trans-eQTL) | C/G | 0.040 | 0.919 | Aldo (a, m) | 0.275 (0.050) | 3.42 × 10−08 | 0.716 | 2.81 × 10−2 |
| 6q26 | rs73013706 | PACRG (0) | PARK2 (20) | G/A | 0.020 | 0.925 | T/E2 (a, m, f) | −0.374 (0.068) | 4.42 × 10−08 | 0 | 7.07 × 10−1 |
| 15q21.2 | rs727479 | CYP19A1 (0) | CYP19A1 (0) | A/C | 0.659 | 0.999 | T/E2 (a, m) | −0.141 (0.015) | 4.49 × 10−21 | 0.814 | 5.44 × 10−2 |