Table 3.
Results from meta-analyses of the HLA subtypes on 17-OHP and P4. Significant associations are marked in bold. Allele dose associations were calculated in each study and then combined (fixed-effect meta-model). Further statistics are given in Table S6.
| HLA Subtype | Phenotype | All | Males | Females | IA FDR | |||
|---|---|---|---|---|---|---|---|---|
| Β | p Value | β | p Value | β | p Value | |||
| B*14*02 | 17-OHP | 0.543 | 6.18 × 10−20 | 0.540 | 8.96 × 10−15 | 0.543 | 3.57 × 10−7 | 9.85 × 10−1 |
| P4 | 0.090 | 1.54 × 10−01 | 0.235 | 1.83 × 10−05 | −0.046 | 6.78 × 10−1 | 2.54 × 10−2 | |
| C*08*02 | 17-OHP | 0.480 | 1.12 × 10−20 | 0.509 | 2.29 × 10−18 | 0.416 | 1.63 × 10−5 | 7.22 × 10−1 |
| P4 | 0.094 | 7.86 × 10−02 | 0.201 | 1.17 × 10−05 | −0.009 | 9.24 × 10−1 | 4.88 × 10−2 | |
| DQA1*01*01 | 17-OHP | 0.092 | 5.09 × 10−06 | 0.095 | 3.33 × 10−05 | 0.090 | 1.86 × 10−2 | 9.85 × 10−1 |
| DQB1*05*01 | 17-OHP | 0.095 | 1.37 × 10−05 | 0.100 | 5.30 × 10−05 | 0.086 | 3.66 × 10−2 | 9.85 × 10−1 |