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Adverse events considered to be associated with naldemedine use.
| Grade 1 | Grade 2 | Grade 3 | Grade 4 | |
|---|---|---|---|---|
| Diarrhea | 61 (20.6%) | 20 (6.8%) | 6 (2%) | 0 (0.0%) |
| Abdominal pain | 7 (2.4%) | 4 (1.4%) | 1 (0.3%) | ― |
| Nausea | 17 (5.7%) | 8 (2.7%) | 3 (1%) | ― |
| Anorexia | 30 (10.1%) | 9 (3%) | 4 (1.4%) | 0 (0.0%) |
| Vomiting | 3 (1%) | 3 (1%) | 2 (0.7%) | 0 (0.0%) |
| Fatigue | 19 (6.4%) | 4 (1.4%) | 3 (1%) | ― |
