NO release platforms to manipulate cardiovascular nitric oxide delivery. (a) Branched polyethylenimine diazeniumdiolate (BPEI/NONOate) was encapsulated into PLGA nanoparticles to release NO in a sustained manner. (b) The mechanism of NO release from the combination of catalytic copper nanoparticles and S-nitroso-N-acetylpenicillamine. (c) The stent, coated with heparin/NONOate nanoparticles (Hep/NONOates), contributed to the long-term release of NO. (d) The light-responsive gatekeeper system for spatiotemporal-controlled NO delivery. Panel (a) is adapted with permission from Reference [108], American Chemical Society. Panel (b) is adapted with permission from Reference [104], American Chemical Society. Panel (c) is reproduced with permission from Reference [109], American Chemical Society. Panel (d) is reproduced with permission from Reference [110], American Chemical Society.