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. 2021 Nov 10;22(22):12166. doi: 10.3390/ijms222212166

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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NO release platforms to manipulate cardiovascular nitric oxide delivery. (a) Branched polyethylenimine diazeniumdiolate (BPEI/NONOate) was encapsulated into PLGA nanoparticles to release NO in a sustained manner. (b) The mechanism of NO release from the combination of catalytic copper nanoparticles and S-nitroso-N-acetylpenicillamine. (c) The stent, coated with heparin/NONOate nanoparticles (Hep/NONOates), contributed to the long-term release of NO. (d) The light-responsive gatekeeper system for spatiotemporal-controlled NO delivery. Panel (a) is adapted with permission from Reference [108], American Chemical Society. Panel (b) is adapted with permission from Reference [104], American Chemical Society. Panel (c) is reproduced with permission from Reference [109], American Chemical Society. Panel (d) is reproduced with permission from Reference [110], American Chemical Society.