Table 2.
Summary of pre-clinical animal models analyzed for this study.
| Author, Year | Ref. | Cells Seeded | Luminal Cell Type | External Cell Type | Length (mm) | Diameter (mm) | Scaffold Type | Localization | |
|---|---|---|---|---|---|---|---|---|---|
| Sheep | Tillman, 2012 | [21] | Yes | PB-EC | None | 60 | 5.0 | Decellularized Artery | Carotid Artery AV Shunt |
| Kaushal, 2001 | [22] | Yes | PB-EC | None | 45 | 4.0 | Decellularized Artery | Carotid Artery | |
| Cho, 2005 | [23] | Yes | BMMNC-EC | BMNC-SMC | 40 | 3.0 | Decellularized Artery | Carotid Artery | |
| Koenneker, 2010 | [24] | Yes | PB-EC | None | 75 | 5.0 | Decellularized Artery | Carotid Artery AV Shunt | |
| Neff, 2011 | [25] | Yes | PB-EC | Vessel SMC | 60 | 5.0 | Decellularized Artery | Carotid Artery | |
| Koch, 2010 | [26] | Yes | None | Vessel SMC | 45 | 5.0 | Hybrid (Firbin-PLA) | Carotid Artery | |
| Ju, 2017 | [27] | Yes | PB-EC | Vessel SMC | 50 | 4.8 | Hybrid (Collagen-PCL) | Carotid Artery | |
| Fukunishi, 2017 | [28] | No | None | None | 15 | 12.0 | Synthetic (PGA-PCL) | Inferior vena cava | |
| Row, 2015 | [29] | Yes | EC | SMC | 45 | 5.0 | Natural (SIS- Fibrin) | Carotid Artery | |
| Aper, 2016 | [30] | Yes | PB-EC | PB-SMC | 90 | 5.6 | Natural (Fibrin + Coagulation Factor XIII) | Carotid Artery | |
| Swartz, 2005 | [31] | Yes | Vessel-EC | Vessel-SMC | 12 | 5.0 | Natural (Firin-Thrombin) | Yugular Vein | |
| Meier, 2014 | [32] | Yes | PB-EC | None | 25 | 4.0 | Natural (Fibrin gel) | Femoral Artery | |
| Ramesh, 2013 | [33] | No | None | None | 130 | 4.0 | Decellularized Vein | Carotid Artery | |
| Aussel, 2017 | [34] | No | None | None | 35 | 6.0 | Natural (Chitosan) | Carotid Artery | |
| Weber, 2018 | [35] | No | None | None | 10 | 4.5 | Natural (Nanocellulose) | Carotid Artery | |
| Goat | Turner, 2006 | [36] | Yes | Vessel-EC | None | 45 | 4.5 | Hybrid (PU + cells) | Carotid Artery |
| Kim, 2007 | [37] | No | None | None | 40 | 4.5 | Decellularized Artery | Carotid Artery | |
| Rabbit | Zheng, 2012 * | [38] | No | None | None | 15 | 2.2 | Synthetic (PCL) | Carotid Artery |
| Cutiongco, 2016 * | [39] | No | None | None | Not reported | 0.9–1 | Synthetic (PVA) | Femoral Artery | |
| Zhang, 2017 * | [40] | No | None | None | 30 | 4.0 | Synthetic (ePTFE) | Abdominal Aorta | |
| Wang, 2016 * | [41] | No | None | None | 10 | 2.2 | Synthetic (PCL) | Carotid Artery | |
| Wise, 2011 * | [42] | No | None | None | 20 | 2.8 | Hybrid (PCL—Elastin) | Carotid Artery | |
| Tillman, 2009 * | [43] | No | None | None | 40 | 5.0 | Hybrid (PCL—collagen) | Aortoiliac Bypass | |
| Evans, 2015 * | [44] | No | None | None | 30–40 | 2.0 | Autologous vein | Yugular Vein | |
| Zhu, 2012 * | [45] | Yes | HOB | None | 5 | 3 | Synthetic (PCL) | Femoral Artery | |
| Ishii, 2008 * | [46] | No | None | None | 24 | 3.6 | Hybrid (PU—collagen—Hyaluronic acid) | Abdominal Aorta | |
| Kajbafzadeh, 2019 * | [47] | No | None | None | Not reported | Not reported | Decellularized Artery | Femoral Arteries | |
| Zhao, 2019 * | [48] | No | None | None | 20 | 2 | Synthetic (PLCL) | Carotid Artery | |
| Bai, 2019 * | [49] | No | None | None | 20 | 2 | Synthetic (PS) | Carotid Artery | |
| Bai, 2018 * | [49] | No | None | None | 20 | 2 | Synthetic (PS) | Carotid Artery | |
| Pig | Koens, 2015 | [50] | No | None | None | 35 | 4 | Natural (elastin-collagen) | Iliac Artery |
| Rotmans, 2005 | [51] | No | None | None | 70 | 5 | Synthetic (PTFE+ CD34 coating) | Carotid Artery AV Shunt | |
| Rothuizen, 2016 | [52] | No | None | None | 40 | 4.2 | Fibrotic capsule tube + PCL | Carotid Artery | |
| Mahara, 2015 | [53] | No | None | None | 250 | 3 | Decellularized Artery | Femoral Artery | |
| Sánchez-Palencia, 2018 * | [54] | No | None | None | 17 | 4.5 | Decellularized SIS | Carotid Artery | |
| Dahan, 2017 | [55] | No | None | None | 45 | 4.0 | Decellularized Artery | Carotid Artery | |
| Valencia Rivero, 2017 | [56] | No | None | None | 150 | 4.0 | Decellularized SIS | Carotid Artery AV Shunt | |
| Zavan, 2008 | [57] | No | None | None | 50 | 4.0 | Natural (Hyaluronan) | Carotid Artery | |
| Wippermann, 2009 | [58] | No | None | None | 10 | 3.4 | Natural (Cellulose) | Carotid Artery | |
| Hinds, 2006 | [59] | No | None | None | 40 | 4.3 | Natural (Ellastin) | Carotid Artery | |
| Pellegata, 2015 | [60] | Yes | hIAECS | None | 50 | 6.0 | Decellularized Artery | Iliac Artery | |
| Dog | Arts, 2002 | [61] | Yes | MVEC | None | 50 | 4.0 | Synthetic (ePTFE) | Carotid Artery |
| Xie, 2010 | [62] | No | None | None | 50 | 6.0 | Poly (carbonate urethane) (PCU) filaments |
Infra-renal aorta | |
| Yokota, 2008 | [63] | No | None | None | 30 | 4.0 | Collagen microsponge with a biodegradable woven polyglycolic acid (core) and poly-L-lactic acid (sheath) fibers. | Carotid Artery | |
| Zhou, 2009 * | [64] | No | None | None | 45 | 3.0 | Decellularized/hybrid | Carotid Artery | |
| Zhou, 2012 | [65] | Yes | PBMC-EC | None | 45 | 3.0 | Decellularized Artery | Carotid Artery | |
| Zhou, 2014 * | [66] | No | None | None | 45 | 3.0 | Hybrid chitosan/poly(e-caprolactone) (CS/PCL) nanofibers | Carotid Artery |
* Additional studies included different from the reported by Skovrind et al [19].