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. 2021 Nov 18;22(22):12431. doi: 10.3390/ijms222212431

Figure 3.

Figure 3

TCDD enriched genes from the mevalonate-dependent isoprenoid biosynthesis pathway. Relative abundance of genes involved in isoprenoid biosynthesis and grouped by enzyme commission (EC) numbers for the mevalonate dependent and 2-C-methyl-D-erythritol 4-phosphate (MEP) pathways in cecum samples from male C57BL6 mice following oral gavage with sesame oil vehicle or 0.3, 3, or 30 µg/kg TCDD every 4 days for 28 days (n = 3). Individual box plots are also numbered with the EC number matching the enzymatic step in pathway schematic. Adjusted p-values (adj. p) were determined by the Maaslin2 R package. Abbreviations: 3-hydroxyl-3-methyl-clutaryl-CoA (HMG-CoA), (R)-5-Phosphomevalonate (mevalonate-5P), (R)-5-Diphosphomevalonate (mevalonate-5PP), 2-C-Methyl-D-erythritol 4-phosphate (MEP), 4-(Cytidine 5′-diphospho)-2-C-methyl-D-erythritol (CDP-ME), 4-(Cytidine 5′-diphospho)-2-C-methyl-D-erythritol (DEP-ME-2P), 2-C-Methyl-D-erythritol 2,4-cyclodiphosphate (MEcPP), and 1-Hydroxy-2-methyl-2-butenyl 4-diphosphate (HMBPP).