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. 2021 Nov 18;22(22):12431. doi: 10.3390/ijms222212431

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Mevalonate-dependent isoprenoid biosynthesis genes are enriched in a published metagenomics dataset of fecal samples from cirrhosis patients. Humann3 analysis of fecal gut microbiomes in healthy (H, red, n = 52), compensated (C, green, n = 48), or decompensated (D, blue, n = 44) cirrhosis for mevalonate-dependent and methyl-D-erythritol 4-phosphate (MEP) pathways. Individual boxplots are numbered with the EC number matching the enzymatic step in pathway schematic. Significance is denoted with a red asterisk (*, adjusted p-values < 0.05) compared to healthy group. Abbreviations.: 3-hydroxyl-3-methyl-clutaryl-CoA (HMG-CoA), (R)-5-Phosphomevalonate (mevalonate-5P), (R)-5-Diphosphomevalonate (mevalonate-5PP), 2-C-Methyl-D-erythritol 4-phosphate (MEP), 4-(Cytidine 5′-diphospho)-2-C-methyl-D-erythritol (CDP-ME), 4-(Cytidine 5′-diphospho)-2-C-methyl-D-erythritol (DEP-ME-2P), 2-C-Methyl-D-erythritol 2,4-cyclodiphosphate (MEcPP), 1-Hydroxy-2-methyl-2-butenyl 4-diphosphate (HMBPP).