Table 1.
Classification of local and systemic adverse reaction severity following vaccination.
| Mild | Moderate | Severe | Grade 4 | |
|---|---|---|---|---|
| Local reactions | ||||
| Redness | >2.0 to 5.0 cm | >5.0 to 10.0 cm | >10.0 cm | Necrosis or exfoliative dermatitis |
| Swelling | >2.0 to 5.0 cm | >5.0 to 10.0 cm | >10.0 cm | Necrosis |
| Pain | Does not interfere with activity | Some interference with activity | Prevents daily activity | Emergency room visit or hospitalization for severe pain at the injection site. |
| Systemic reactions | ||||
| Fatigue | Does not interfere with activity | Some interference with activity | Prevents daily activity | Emergency room visit or hospitalization for severe fatigue. |
| Headache | Does not interfere with activity | Some interference with activity | Prevents daily activity | Emergency room visit or hospitalization for severe headache. |
| Muscle/Joint pain | Does not interfere with activity | Some interference with activity | Prevents daily activity | Emergency room visit or hospitalization for severe muscle pain or severe joint pain. |
| Gastrointestinal symptoms | Emesis 1 or 2 times and/or 2 or 3 loose stools in 24 h | Emesis > 2 times and/or 4 or 5 loose stools in 24 h | Requiring intravenous hydration and/or ≥6 loose stools in 24 h | Emergency room visit or hospitalization for severe vomiting and/or diarrhea. |