Table 3.

HA interactions. RHAMM, receptor for hyaluronan-mediated motility; LYVE-1, lymphatic vessel endothelial hyaluronan receptor 1; TLR-4, Toll-like receptors 4; TSG6, TNF-stimulated gene 6; GHAP, glial hyaluronate-binding protein; LMW-HA, low molecular weight HA.

HA and ECM Receptors Interactions
	Function
CD44 Receptor for hyaluronan-mediated motility (RHAMM)	Binding HA: anti-inflammatory, wound healing, antiangiogenic, immunosuppressive
Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1)	Lymphatic transport of leukocytes
Toll-like receptor 4 (TLR-4)	Binding LMW-HA: pro-inflammatory
TNF-stimulated gene 6 (TSG-6)	Tissue protective and anti-inflammatory
Glial hyaluronate-binding protein (GHAP)	Reduces the spread of inflammatory cells in nerve tissue
Neurocan Versican Aggrecan	Development, cell migration, maturation and differentiation, cell survival, and tissue homeostasis