Table 2.
The mostly expressed cytokines by different cell types classified according to their biological function.
| Cell Type/ Biological Function of Cytokine |
Human AT-MSCs | Rabbit AT-MSCs | HUVECs | Rabbit EPCs |
|---|---|---|---|---|
| Pro-angiogenic | MCP-1, GRO, Angiogenin, TGF-β 2, IL-8, IL-6, Osteopontin | TGF-β 2, Osteopontin, IL-8, IL-5, IL-3, TNF-β, Leptin, IL-1a | MCP-1, GRO, Angiogenin, IL-8, IL-6, MIF, TGF-β 2, GCP-2 | TGF-β 2, Osteopontin, GRO, IL-8, IL-5, IL-3, TNF-β, MCP-3 |
| Anti-angiogenic | TIMP-2, TIMP-1 | TIMP-2 | TIMP-2, TIMP-1 | TIMP-2 |
| Pro-inflammatory | TIMP-1, MCP-1, GRO, Angiogenin, TGF-β 2 (according to circumstances), IL-8, LIF (according to circumstances), IL-6, Osteopontin | TGF-β 2 and LIF (according to circumstances), Osteopontin, IL-8, IL-3, TNF-β, Leptin, IL-1a | MCP-1, GRO, Angiogenin, IL-8, TIMP-1, IL-6, MIF, TGF-β 2 (according to circumstances), GCP-2 | TGF-β 2 (according to circumstances), Osteopontin, GRO, LIF (according to circumstances), IL-8, IL-3, TNF-β, MCP-3 |
| Anti-inflammatory | TIMP-2, TGF-β 2 and LIF (according to circumstances) | TIMP-2, TGF-β 2 and LIF (according to circumstances), IL-5 | TIMP-2, TGF-β 2 (according to circumstances) | TIMP-2, TGF-β 2 and LIF (according to circumstances), IL-5 |
| Neuroregulatory | LIF | LIF | LIF | LIF |
| Adipokines | TIMP-2, TIMP-1, MCP-1, GRO, Angiogenin, TGF-β 2, IL-8, LIF, IL-6, Osteopontin | TIMP-2, TGF-β 2, LIF, Osteopontin, IL-8, IL-5, Leptin, IL-1a | MCP-1, TIMP-2, GRO, Angiogenin, IL-8, TIMP-1, IL-6, MIF, TGF-β 2, GCP-2 | TIMP-2, TGF-β 2, Osteopontin, GRO, LIF, IL-8, IL-5, MCP-3 |