BBB	blood–brain barrier
BPF	brain parenchymal fraction
CNS	central nervous system
DAMPs	damage-associated molecular patterns
DD	disease duration
DEP	differentially expressed protein
DMT	disease-modifying therapy
EAE	experimental autoimmune encephalomyelitis
EDSS	expanded disability status scale
ER	endoplasmic reticulum
ERSR	endoplasmic reticulum stress response
GANAB	glucosidase II alpha subunit
GM	grey matter
HCs	healthy controls
i.m.	intramuscular injection
IFI35	interferon-induced protein 35
IFN	interferon
LL	lesion load
MRS	Modified Rio Score
MS	multiple sclerosis
other th.	patients treated with other than IFN therapy
PBMCs	peripheral blood mononuclear cells
PBS	phosphate buffered saline
pGREY	peripheral grey matter
RRun	relapsing remitting untreated patients
RS	Rio Score
s.c.	subcutaneous injection
TBV	total brain volume
UPR	unfolded protein response
vCSF	ventricular cerebrospinal fluid
WM	white matter